https://scholars.lib.ntu.edu.tw/handle/123456789/526460
Title: | Epstein-Barr virus associated post-transplantation lymphoproliferative disorder with hemophagocytosis in a child with Wiskott-Aldrich syndrome | Authors: | Wang I.J. MENG-YAO LU BOR-LUEN CHIANG WEI-CHOU LIN Lin D.T. Lin K.-H. |
Issue Date: | 2005 | Journal Volume: | 45 | Journal Issue: | 3 | Start page/Pages: | 340-343 | Source: | Pediatric Blood and Cancer | Abstract: | A 23-month-old boy with Wiskott-Aldrich syndrome (WAS) received human leukocyte antigen (HLA)-one locus mismatched, unmanipulated allogeneic bone marrow graft from his mother. An Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disorder (PTLD) of donor cell origin and hemophagocytosis syndrome with fever, lymphadenopathy, hepatosplenomegaly, seizures, involuntary movements and pancytopenia developed 52 days after transplantation. It was difficult to decide on the treatment strategy because the patient presented with B-cell hyperplasia that morphologically appeared malignant but was oligoclonal by heavy-chain analyses. Despite of donor leukocyte transfusion, low dose chemotherapy, and anti-B cell monoclonal antibody immunotherapy, the patient died 107 days after transplantation. ? 2004 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-23044474854&doi=10.1002%2fpbc.20191&partnerID=40&md5=9e96ac7a1e361906d7fe0e194e27361e https://scholars.lib.ntu.edu.tw/handle/123456789/526460 |
ISSN: | 1545-5009 | DOI: | 10.1002/pbc.20191 | SDG/Keyword: | aciclovir; alpha interferon; antineoplastic agent; B lymphocyte antibody; busulfan; CD20 antibody; CD34 antigen; cyclophosphamide; cyclosporin A; cytotoxic agent; HLA antigen; immunoglobulin; immunoglobulin M; immunoglobulin mu chain; immunosuppressive agent; lactate dehydrogenase; methotrexate; monoclonal antibody; prednisolone; steroid; thymocyte antibody; vincristine; allogenic bone marrow transplantation; article; B cell hyperplasia; cancer combination chemotherapy; cancer immunotherapy; case report; cause of death; clinical feature; Epstein Barr virus; fever; hemophagocytic syndrome; hepatosplenomegaly; HLA matching; human; human tissue; hyperplasia; involuntary movement; leukocyte transfusion; low drug dose; lymph node biopsy; lymphadenopathy; lymphoproliferative disease; male; pancytopenia; polymerase chain reaction; preschool child; priority journal; prognosis; risk factor; seizure; virus infection; Wiskott Aldrich syndrome; Bone Marrow Transplantation; Epstein-Barr Virus Infections; Fatal Outcome; Histiocytosis, Non-Langerhans-Cell; Humans; Infant; Lymphoproliferative Disorders; Male; Tomography, X-Ray Computed; Wiskott-Aldrich Syndrome |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.