https://scholars.lib.ntu.edu.tw/handle/123456789/527294
標題: | The association between transforming growth factor-β gene promoter C-509T polymorphism and Chinese children with Henoch-Schönlein purpura | 作者: | YAO-HSU YANG Lai H.-J. Kao C.-K. YU-TSAN LIN BOR-LUEN CHIANG |
公開日期: | 2004 | 卷: | 19 | 期: | 9 | 起(迄)頁: | 972-975 | 來源出版物: | Pediatric Nephrology | 摘要: | Many cytokines, including transforming growth factor-β (TGF-β) and tumor necrosis factor-α (TNF-α), are involved in the inflammatory process of Henoch-Sch?nlein purpura (HSP). The objective of this study was to investigate whether TGF-β C-509T and TNF-α G-308A polymorphisms are associated with childhood HSP. The loci of interest were amplified from genomic DNA using specific primers and polymerase chain reaction, and these two polymorphisms were compared between Chinese children with HSP and healthy controls. The disease severities evaluated and expressed as symptom score of patients with different genotypes were also compared. The TGF-β -509 TT genotype was more common in children with HSP than controls (31% vs. 8%, P =0.03, odds ratio= 4.95). The allelic frequencies of TGF-β -509, genotypic and allelic frequencies of TNF-α -308 were not significantly different. Patients with the TT genotype had more severe clinical presentations than non-TT (TC+CC) patients (4.1±0.42 vs. 2.7+0.31, P =0.018). These results suggest that the TT genotype of the C-509T polymorphism of the TGF-β gene might be related to the susceptibility of Chinese children to HSP and to the severity of this disease. ? IPNA 2004. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-4544369836&doi=10.1007%2fs00467-004-1547-4&partnerID=40&md5=7ad6f0d41cba73112c65576cd3002112 https://scholars.lib.ntu.edu.tw/handle/123456789/527294 |
ISSN: | 0931-041X | DOI: | 10.1007/s00467-004-1547-4 | SDG/關鍵字: | genomic DNA; transforming growth factor alpha; transforming growth factor beta; anaphylactoid purpura; article; child; Chinese; clinical article; clinical feature; controlled study; disease severity; female; gene amplification; gene frequency; gene locus; genetic polymorphism; genetic predisposition; genetic susceptibility; genotype; human; male; polymerase chain reaction; priority journal; promoter region; rating scale; restriction fragment length polymorphism; scoring system; statistical analysis; statistical significance; Adolescent; Alleles; Child; Child, Preschool; China; Female; Genotype; Humans; Infant; Male; Polymorphism, Genetic; Promoter Regions (Genetics); Purpura, Schoenlein-Henoch; Transforming Growth Factor beta |
顯示於: | 醫學系 |
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