https://scholars.lib.ntu.edu.tw/handle/123456789/531729
標題: | Natural and non-natural antioxidative compounds: potential candidates for treatment of vascular calcification | 作者: | CHIA-TER CHAO Yeh H.-Y. Tsai Y.-T. Chuang P.-H. Yuan T.-H. JENQ-WEN HUANG HUEI-WEN CHEN |
公開日期: | 2019 | 出版社: | Springer Nature | 卷: | 5 | 期: | 1 | 起(迄)頁: | 145 | 來源出版物: | Cell Death Discovery | 摘要: | Vascular calcification (VC) is highly prevalent in patients with advanced age, or those with chronic kidney disease and diabetes, accounting for substantial global cardiovascular burden. The pathophysiology of VC involves active mineral deposition by transdifferentiated vascular smooth muscle cells exhibiting osteoblast-like behavior, building upon cores with or without apoptotic bodies. Oxidative stress drives the progression of the cellular phenotypic switch and calcium deposition in the vascular wall. In this review, we discuss potential compounds that shield these cells from the detrimental influences of reactive oxygen species as promising treatment options for VC. A comprehensive summary of the current literature regarding antioxidants for VC is important, as no effective therapy is currently available for this disease. We systematically searched through the existing literature to identify original articles investigating traditional antioxidants and novel compounds with antioxidant properties with regard to their effectiveness against VC in experimental or clinical settings. We uncovered 36 compounds with antioxidant properties against VC pathology, involving mechanisms such as suppression of NADPH oxidase, BMP-2, and Wnt/β-catenin; anti-inflammation; and activation of Nrf2 pathways. Only two compounds have been tested clinically. These findings suggest that a considerable opportunity exists to harness these antioxidants for therapeutic use for VC. In order to achieve this goal, more translational studies are needed. ? 2019, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075009663&doi=10.1038%2fs41420-019-0225-z&partnerID=40&md5=14d9fee18adb555b6dfa2c7c26032e41 https://scholars.lib.ntu.edu.tw/handle/123456789/531729 |
ISSN: | 2058-7716 | DOI: | 10.1038/s41420-019-0225-z |
顯示於: | 醫學系 |
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