https://scholars.lib.ntu.edu.tw/handle/123456789/533362
Title: | Differential effects of progestins and estrogens on long control regions of human papillomavirus types 16 and 18 | Authors: | YEN-HUI CHEN Huang L.-H. Chen T.-M. |
Issue Date: | 1996 | Journal Volume: | 224 | Journal Issue: | 3 | Start page/Pages: | 651-659 | Source: | Biochemical and Biophysical Research Communications | Abstract: | We have studied effects of a series of progestins and estrogens on regulation of human papillomavirus (IBV) types 16 and 18 gene expression via long control region (LCR), using a transient expression assay which represented the episomal state of HPVs in precancerous lesions. Results showed that HPV gene expression induced by these steroid analogs were diverse. Gene expression via HPV16-LCR was upregulated 2-3 fold under treatment with 10-7 M estriol, 17β-estradiol, and several progestins including pregnenolone, 17α-hydroxy-progesterone, norethynodrel and cyproterone acetate. However, transcription via HPV18-LCR was not or weakly stimulated by these analogs. Our results can divide these analogs into HPV-enhancing and HPV-nonenhancing groups and accordingly impact the relative risk of individual oral contraceptive ingredient in cervical carcinogenesis. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030601195&doi=10.1006%2fbbrc.1996.1080&partnerID=40&md5=c7fe0c5054d079be2dee01e8914d2f79 https://scholars.lib.ntu.edu.tw/handle/123456789/533362 |
ISSN: | 0006291X | DOI: | 10.1006/bbrc.1996.1080 | SDG/Keyword: | 17 hydroxypregnenolone; cyproterone acetate; estradiol; estriol; estrogen; gestagen; noretynodrel; oral contraceptive agent; pregnenolone; article; controlled study; DNA transcription; episome; gene expression regulation; human; human cell; nonhuman; precancer; priority journal; risk; uterine cervix cancer; virus genome; Wart virus |
Appears in Collections: | 臨床藥學研究所 |
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