https://scholars.lib.ntu.edu.tw/handle/123456789/535486
標題: | Herpes zoster in HIV-1-infected patients in the era of highly active antiretroviral therapy: A prospective observational study | 作者: | CHIEN-CHING HUNG Hsiao C.-F. Wang J.-L. Chen M.-Y. SZU-MIN HSIEH WANG-HUEI SHENG SHAN-CHWEN CHANG |
公開日期: | 2005 | 卷: | 16 | 期: | 10 | 起(迄)頁: | 673-676 | 來源出版物: | International Journal of STD and AIDS | 摘要: | Between June 1994 and May 2003, 93 of 716 (13.0%) HIV-infected patients with a median baseline cell differentiation CD4+ count of 61 × 10 6 cells/L (range, 1-1206 × 106 cells/L) developed 103 episodes of herpes zoster [HZ], with an incidence of 5.67 per 100 person-years (PY). The incidence of HZ in the pre-highly active antiretroviral therapy (HAART) era (17.21 per 100 PY) was significantly higher than that in the post-HAARTera (5.05 per 100 PY) (P < 0.0001). In the first six months of enrolment, the incidence of HZ was significantly higher than that between six and 12 months both in the pre-HAART (27.65 per 100 PY versus 8.43 per 100 PY, P = 0.02) and post-HAART era (17.79 per 100 PY versus 3.39 per 100 PY, P < 0.0001). In multivariate analyses, only baseline CD4+ count remained a significant risk factor associated with HZ. HZ did not increase mortality rate either in the pre-HAART or post-HAART era, although the risk for HIV progression was significantly higher in patients with HZ (adjusted odds ratio [OR], 1.747, 95% confidence interval, 1.037-2.943). We conclude that the incidence of HZ was highest in the first six months of enrolment in patients at late stage of HIV infection, which did not increase with the introduction of HAART. Baseline CD4+ lymphocyte count was the most significant risk factor associated with development of HZ. HZ was associated with increased risk for HIV progression, but not mortality. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-27344431604&doi=10.1258%2f095646205774357271&partnerID=40&md5=fc8f7a5d4a931a87604553795ad550a5 https://scholars.lib.ntu.edu.tw/handle/123456789/535486 |
ISSN: | 0956-4624 | DOI: | 10.1258/095646205774357271 | SDG/關鍵字: | antivirus agent; CD4 antigen; RNA directed DNA polymerase inhibitor; adult; aged; article; cell differentiation; clinical trial; controlled clinical trial; controlled study; disease association; disease course; female; herpes zoster; high risk patient; highly active antiretroviral therapy; human; human cell; incidence; infection risk; lymphocyte; lymphocyte differentiation; major clinical study; male; mortality; multivariate analysis; priority journal; prospective study; risk assessment; risk factor; statistical significance; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Herpes Zoster; Herpesvirus 3, Human; HIV Infections; HIV-1; Humans; Prevalence; Prospective Studies |
顯示於: | 醫學系 |
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