https://scholars.lib.ntu.edu.tw/handle/123456789/536737
標題: | Efficacy and safety of imidapril in patients with essential hypertension: A double-blind comparison with captopril | 作者: | Huang, Por-Jau KUO-LIONG CHIEN MING-FONG CHEN LING-PING LAI FU-TIEN CHIANG |
公開日期: | 2001 | 卷: | 95 | 期: | 3 | 起(迄)頁: | 146 | 來源出版物: | Cardiology | 摘要: | In this 12-week, double-blind, parallel-group, comparative trial, 57 adult patients with mild-to-moderate hypertension were randomly allocated to receive imidapril or captopril, initially at a dose of 5 mg once a day and 25 mg twice daily, respectively. After 4 weeks of therapy, the dose of each drug was increased twice if diastolic blood pressure (DBP) remained ? 90 mm Hg. Both treatments effectively lowered DBP in a comparable manner. Mean changes from baseline in DBP at 12 weeks were -9.9 mm Hg for imidapril and -8.8 mm Hg for captopril (p = 0.488). Responder rates in patients receiving active treatment for at least 6 weeks were 53.9% for imidapril and 48% for captopril (p = 0.676). Both treatments were well tolerated. Adverse drug reactions were observed in 20.7% (6/29) of the imidapril group and 46.4% (13/28) of the captopril group (p < 0.05). A cough was the most frequent side effect, reported in 13.8% of the imidapril group and 35.7% of the captopril group. The results indicate that imidapril is as effective as captopril in the treatment of hypertension. Imidapril produces less adverse effects compared with captopril. ? 2001 S. Karger AG, Basel. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034907453&doi=10.1159%2f000047361&partnerID=40&md5=e85aec06c634dbf4d37b997b46093f2d https://scholars.lib.ntu.edu.tw/handle/123456789/536737 http://ntur.lib.ntu.edu.tw//handle/246246/95170 |
ISSN: | 0008-6312 | DOI: | 10.1159/000047361 | SDG/關鍵字: | captopril; imidapril; adult; article; clinical trial; controlled clinical trial; controlled study; coughing; diarrhea; double blind procedure; drug efficacy; drug safety; drug tolerability; dysgeusia; essential hypertension; female; good clinical practice; human; impotence; major clinical study; male; priority journal; proteinuria; pruritus; quality of life; randomized controlled trial; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Captopril; Cough; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension; Imidazoles; Imidazolidines; Male; Middle Aged; Taiwan; Treatment Outcome |
顯示於: | 醫學系 |
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