Efficacy and safety of imidapril in patients with essential hypertension: A double-blind comparison with captopril
Journal
Cardiology
Journal Volume
95
Journal Issue
3
Pages
146
Date Issued
2001
Author(s)
Abstract
In this 12-week, double-blind, parallel-group, comparative trial, 57 adult patients with mild-to-moderate hypertension were randomly allocated to receive imidapril or captopril, initially at a dose of 5 mg once a day and 25 mg twice daily, respectively. After 4 weeks of therapy, the dose of each drug was increased twice if diastolic blood pressure (DBP) remained ? 90 mm Hg. Both treatments effectively lowered DBP in a comparable manner. Mean changes from baseline in DBP at 12 weeks were -9.9 mm Hg for imidapril and -8.8 mm Hg for captopril (p = 0.488). Responder rates in patients receiving active treatment for at least 6 weeks were 53.9% for imidapril and 48% for captopril (p = 0.676). Both treatments were well tolerated. Adverse drug reactions were observed in 20.7% (6/29) of the imidapril group and 46.4% (13/28) of the captopril group (p < 0.05). A cough was the most frequent side effect, reported in 13.8% of the imidapril group and 35.7% of the captopril group. The results indicate that imidapril is as effective as captopril in the treatment of hypertension. Imidapril produces less adverse effects compared with captopril. ? 2001 S. Karger AG, Basel.
SDGs
Other Subjects
captopril; imidapril; adult; article; clinical trial; controlled clinical trial; controlled study; coughing; diarrhea; double blind procedure; drug efficacy; drug safety; drug tolerability; dysgeusia; essential hypertension; female; good clinical practice; human; impotence; major clinical study; male; priority journal; proteinuria; pruritus; quality of life; randomized controlled trial; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Captopril; Cough; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension; Imidazoles; Imidazolidines; Male; Middle Aged; Taiwan; Treatment Outcome
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
19.pdf
Size
148.03 KB
Format
Adobe PDF
Checksum
(MD5):0fe5d0d71adcb1160530aeca950024da