https://scholars.lib.ntu.edu.tw/handle/123456789/537123
標題: | Prophylactic oral antibiotics in prevention of recurrent cholangitis after the Kasai portoenterostomy | 作者: | Bu L.-N. HUEY-LING CHEN Chang C.-J. YEN-HSUAN NI HONG-YUAN HSU HONG-SHIEE LAI WEN-MING HSU MEI-HWEI CHANG |
公開日期: | 2003 | 出版社: | W.B. Saunders | 卷: | 38 | 期: | 4 | 起(迄)頁: | 590-593 | 來源出版物: | Journal of Pediatric Surgery | 摘要: | Purpose: The aim of this study was to evaluate the efficacy of trimethoprim-sulfamethoxazole (TMP/SMZ) and neomycin as the prophylactic agents against the recurrence of cholangitis in children with biliary atresia (BA) after a Kasai portoenterostomy. Methods: Nineteen BA patients aged 0 to 2 years, who had one episode of cholangitis after a Kasai portoenterostomy, were recruited in this study. Patients were assigned randomly into 2 groups: one (9 cases) with TMP/SMZ (TMP 4 mg/kg/d and SMZ 20 mg/kg/d, divided in 2 doses) and the other (10 cases) with neomycin (25 mg/kg/d, qid, 4 days a week). Another 18 BA patients aged 0 to 2 years, with cholangitis but not put on long-term prophylaxis, served as the historical control group. Results: The mean prophylactic periods were 14.6 months and 14.7 months in the TMP/SMZ and neomycin groups. Patients who received prophylaxis with either TMP/SMZ or neomycin had lower recurrence rates of cholangitis than those in the control group (P = .042 and .011). There was no difference in the recurrence rates of cholangitis between the TMP/SMZ and neomycin groups (P = .641). The survival rates were higher in the TMP/SMZ and neomycin groups than in the control group (P = .09 and .018). Conclusions: Use of TMP/SMZ or neomycin is effective as a prophylactic agent against the recurrence of cholangitis after the Kasai portoenterostomy, but there is no difference in efficacy between these 2 regimens. Copyright 2003, Elsevier Science (USA). All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037388861&doi=10.1053%2fjpsu.2003.50128&partnerID=40&md5=753be6ec1568ad059062c18a770fb486 https://scholars.lib.ntu.edu.tw/handle/123456789/537123 |
ISSN: | 0022-3468 | DOI: | 10.1053/jpsu.2003.50128 | SDG/關鍵字: | cotrimoxazole; neomycin; analysis of variance; antibiotic prophylaxis; article; blood culture; cholangitis; clinical article; clinical trial; controlled clinical trial; controlled study; drug efficacy; female; follow up; human; infant; infection prevention; leukocyte count; liver function test; long term care; male; portoenterostomy; postoperative infection; preschool child; priority journal; randomized controlled trial; recurrent disease; survival rate; treatment outcome; urine culture |
顯示於: | 醫學系 |
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