https://scholars.lib.ntu.edu.tw/handle/123456789/539412
標題: | Cardiopulmonary involvement in pediatric systemic lupus erythematosus: A twenty-year retrospective analysis | 作者: | Yeh T.-T. YAO-HSU YANG YU-TSAN LIN Lu C.-S. BOR-LUEN CHIANG |
公開日期: | 2007 | 卷: | 40 | 期: | 6 | 起(迄)頁: | 525-531 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background and Purpose: Cardiovascular and pulmonary involvement is frequent among patients with systemic lupus erythematosus (SLE). It is important that the frequency and characteristics of pulmonary and cardiovascular involvement in childhood-onset SLE are understood. Thus, we conducted a retrospective analysis of childhood-onset SLE at a tertiary medical center in Taipei. Methods: Children with SLE diagnosed at the National Taiwan University Hospital between 1985 and 2004 were evaluated by chart review. Records included the age at diagnosis, gender, family history, presenting manifestations with American Rheumatism Association criteria and initial laboratory data, other associated complications and duration of follow-up. Results: A total of 157 cases were included. The male-to-female ratio was 18:82, with the mean age at diagnosis 12.2 years. Overall, pulmonary and cardiovascular involvements were recorded in 89 patients (56.7%) and 75 patients (47.8%), respectively. Among the more frequent lung disorders were pneumonia treated under hospitalization (in 36.9% of patients), increased pulmonary interstitial marking or infiltration (35.0%), and pleuritis (33.1%). The more common cardiovascular manifestations included cardiomegaly (in 33.8%), pericarditis (28.7%) and arrhythmia/conduction anomaly (12.7%). Conclusions: The frequencies of pulmonary and cardiovascular complications were high. Blood creatinine >1 mg/dL, hematuria and anemia with hemoglobin <12 g/dL obtained at diagnosis of SLE were associated with cardiovascular complications during the disease course, while anti-double stranded DNA at diagnosis was associated with pulmonary complications. ? 2007 Journal of Microbiology, Immunology and Infection. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-40649105744&partnerID=40&md5=218ac872ec61db16a72851cd7172eff2 https://scholars.lib.ntu.edu.tw/handle/123456789/539412 |
ISSN: | 1684-1182 | SDG/關鍵字: | creatinine; double stranded DNA; hemoglobin; adolescent; article; atelectasis; cardiomegaly; cardiovascular disease; child; clinical feature; congestive heart failure; creatinine blood level; disease course; ECG abnormality; family history; female; follow up; gender; heart arrhythmia; heart atrium enlargement; heart murmur; heart muscle conduction disturbance; heart ventricle hypertrophy; heart ventricle septum defect; hematuria; hospitalization; human; incidence; interstitial lung disease; laboratory test; lung collapse; lung disease; lung edema; lung hemorrhage; lung interstitium; major clinical study; male; medical record review; medical society; onset age; pericarditis; pleurisy; pneumonia; pneumothorax; pulmonary hypertension; retrospective study; systemic lupus erythematosus; tertiary health care; Adolescent; Age of Onset; Child; Child, Preschool; Female; Heart Diseases; Humans; Lung Diseases; Lupus Erythematosus, Systemic; Male; Retrospective Studies; Taiwan |
顯示於: | 醫學系 |
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