https://scholars.lib.ntu.edu.tw/handle/123456789/543851
Title: | Psoriasis and the risk of pneumonia: A population-based study | Authors: | Kao L.-T. Lee, Cha-Ze SHIH-PING LIU Tsai M.-C. Lin H.-C. |
Issue Date: | 2014 | Publisher: | Public Library of Science | Journal Volume: | 9 | Journal Issue: | 12 | Start page/Pages: | e116077 | Source: | PLoS ONE | Abstract: | Background: Psoriasis is a prevalent autoimmune disorder. Various studies have reported on the relationship between psoriasis and chronic diseases but very few have explored the association between psoriasis and subsequent acute infection. This retrospective cohort study aimed to compare the risk of pneumonia between subjects with and those without psoriasis. Methods: The medical records of 14,022 patients with psoriasis and 14,022 without psoriasis were obtained from the Taiwan Longitudinal Health Insurance Database 2000. Each patient was followed-up for a three-year period. Cox proportional hazard regressions were performed to compare difference of subsequent pneumonia incidence between subjects with and those without psoriasis. Results: There were 206 (1.47%) subjects with psoriasis and 138 (0.98%) without psoriasis hospitalized for pneumonia. By Cox proportional hazard regressions analysis, the HR (hazard ratio) of pneumonia requiring hospitalization for patients with psoriasis was 1.50 (95% confidence interval [CI]: 1.21-1.86) compared to patients without psoriasis. The adjusted HR was 1.40 (95% CI: 1.12-1.73). The adjusted HR of pneumonia hospitalization for subjects with mild and severe psoriasis was 1.36 (95% CI: 1.09-1.70) and 1.68 (95% CI: 1.12-2.52), respectively, compared to those without psoriasis. Conclusions: Patients with psoriasis have significantly higher incidence of pneumonia compared to those without psoriasis. ? 2014 Kao et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919908947&doi=10.1371%2fjournal.pone.0116077&partnerID=40&md5=1b4b8e8c36524cdf2a8ecddbfa14af8f https://scholars.lib.ntu.edu.tw/handle/123456789/543851 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0116077 | SDG/Keyword: | biological product; cyclosporin; methotrexate; retinoid; adult; aged; Article; bacterial pneumonia; cohort analysis; controlled study; disease severity; female; follow up; high risk population; hospitalization; human; major clinical study; male; medical record review; morbidity; photochemotherapy; phototherapy; pneumonia; population research; psoriasis; retrospective study; risk assessment; Streptococcus pneumonia; Taiwan; ultraviolet B radiation; virus pneumonia; complication; middle aged; pneumonia; psoriasis; risk; young adult; Adult; Cohort Studies; Female; Hospitalization; Humans; Male; Middle Aged; Pneumonia; Psoriasis; Retrospective Studies; Risk; Taiwan; Young Adult |
Appears in Collections: | 醫學系 |
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