https://scholars.lib.ntu.edu.tw/handle/123456789/544213
標題: | Investigation of Urodynamic Characteristics and Bladder Sensory Function in the Early Stages of Diabetic Bladder Dysfunction in Women With Type 2 Diabetes | 作者: | Lee W.-C. HUEY-PEIR WU TONG-YUAN TAI HONG-JENG YU Chiang P.-H. |
公開日期: | 2009 | 卷: | 181 | 期: | 1 | 起(迄)頁: | 198-203 | 來源出版物: | Journal of Urology | 摘要: | Purpose: We studied urodynamic characteristics and bladder sensory function in the early stages of diabetic bladder dysfunction in diabetic women. Materials and Methods: A total of 86 consecutive type 2 diabetic women with minimal confounders of voiding dysfunction followed at a diabetes clinic were prospectively enrolled and subjected to urodynamic studies. The sensory response of Aδ and C fibers of the bladder was measured by intravesical current perception threshold testing at frequencies of 250 and 5 Hz, respectively. Results: Of these 86 women 30 (34.9%) were classified as having detrusor underactivity, 12 (14.0%) presented signs of detrusor overactivity, 11 (12.8%) were referred to as having bladder outlet obstruction and 33 (38.4%) showed normal detrusor function on urodynamics. The normal detrusor function group was the reference group. The detrusor underactivity group showed impaired emptying function and decreased sensation on cystometry and intravesical current perception threshold testing. The detrusor overactivity group showed impaired storage and emptying function but had no significant changes in intravesical current perception threshold values. When the normal detrusor function group and detrusor underactivity group were pooled to perform multivariate analysis, an increase in current perception threshold values was associated with a decrease in bladder voiding efficiency on 5 and 250 Hz current perception threshold testing. Conclusions: Our data provide the electrophysiological evidence that indicates an association between impaired Aδ as well as C fiber bladder afferent pathways and poor emptying function in diabetic women with detrusor underactivity. Diabetes can affect the bladder presumably via peripheral pathogenetic mechanisms to induce detrusor overactivity with impaired contractility. ? 2009 American Urological Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-57149089422&doi=10.1016%2fj.juro.2008.09.021&partnerID=40&md5=73571c1afb478437e2c909e833a0fd1a https://scholars.lib.ntu.edu.tw/handle/123456789/544213 |
ISSN: | 0022-5347 | DOI: | 10.1016/j.juro.2008.09.021 | SDG/關鍵字: | adult; aged; article; bladder dysfunction; bladder emptying; bladder neck stenosis; controlled study; disease classification; female; human; major clinical study; non insulin dependent diabetes mellitus; overactive bladder; priority journal; urodynamics; Aged; Diabetes Complications; Diabetes Mellitus, Type 2; Disease Progression; Female; Humans; Middle Aged; Sensation; Urinary Bladder; Urinary Bladder Diseases; Urodynamics |
顯示於: | 醫學系 |
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