https://scholars.lib.ntu.edu.tw/handle/123456789/545300
標題: | β-glycoprotein I-dependent anti-cardiolipin antibodies associated with periodontitis in patients with systemic lupus erythematosus | 作者: | CHEN-YING WANG Chyuan I.-T. Wang Y.-L. YEN-PING KUO Chang C.-W. KING-JEAN WU PING-NING HSU Nagasawa T. Wara-Aswapati N. YI-WEN CHEN |
公開日期: | 2015 | 出版社: | American Academy of Periodontology | 卷: | 86 | 期: | 8 | 起(迄)頁: | 995-1004 | 來源出版物: | Journal of Periodontology | 摘要: | Background: It was reported that patients with systemic lupus erythematosus (SLE) exhibited increased levels of anticardioli-pin (anti-CL) antibodies, a class of antiphospholipid antibodies associated with thrombosis. β2-glycoprotein I (β2GPI) has been considered as the actual target antigen for anti-CL antibodies. This study investigates the association of periodontal infection with anti-CL antibodies in patients with SLE. Methods: Fifty-three SLE female patients and 56 healthy female volunteers were recruited in this case-control study. All participants received periodontal examinations. The presence of Porphyromonas gingivalis and Treponema denticola in saliva and plaque samples was detected by polymerase chain reaction. Levels of serum anti-CL and anti-β2GPI antibodies were examined using enzyme-linked immunosorbent assay. Results: Patients with SLE exhibited more periodontal attachment loss and increased titers of serum anti-CL and anti-β2GPI antibodies compared with healthy controls. Patients with active SLE who harbored P. gingivalis or P. gingivalis together with T. denticola intraorally exhibited significantly higher anti-CL and anti-β2GPI antibodies than those without these bacteria. Anti-CL and anti-β2GPI antibody levels correlated positively with clinical attachment level. Furthermore, increased anti-β2GPI antibody levels were significantly associated with C-reactive protein and erythrocyte sedimentation rate. Conclusions: Elevated anti-CL and anti-β2GPI antibody levels were associated with periodontopathic bacteria and periodontal breakdown in patients with SLE. Periodontitis might be a modifiable risk factor for SLE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938259773&doi=10.1902%2fjop.2015.140664&partnerID=40&md5=b375e555b7759b2b0706e54a5531a41c https://scholars.lib.ntu.edu.tw/handle/123456789/545300 |
ISSN: | 0022-3492 | DOI: | 10.1902/jop.2015.140664 | SDG/關鍵字: | beta2 glycoprotein 1; C reactive protein; cardiolipin antibody; creatinine; adult; aged; blood; case control study; classification; cohort analysis; comparative study; erythrocyte sedimentation rate; female; human; immunology; microbiology; middle aged; periodontal disease; periodontal index; periodontal pocket; periodontitis; Porphyromonas gingivalis; saliva; systemic lupus erythematosus; thrombocyte count; tooth plaque; Treponema denticola; Adult; Aged; Antibodies, Anticardiolipin; beta 2-Glycoprotein I; Blood Sedimentation; C-Reactive Protein; Case-Control Studies; Cohort Studies; Creatinine; Dental Plaque; Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Platelet Count; Porphyromonas gingivalis; Saliva; Treponema denticola |
顯示於: | 醫學系 |
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