β-glycoprotein I-dependent anti-cardiolipin antibodies associated with periodontitis in patients with systemic lupus erythematosus
Journal
Journal of Periodontology
Journal Volume
86
Journal Issue
8
Pages
995-1004
Date Issued
2015
Author(s)
Chyuan I.-T.
Wang Y.-L.
Chang C.-W.
Nagasawa T.
Wara-Aswapati N.
Abstract
Background: It was reported that patients with systemic lupus erythematosus (SLE) exhibited increased levels of anticardioli-pin (anti-CL) antibodies, a class of antiphospholipid antibodies associated with thrombosis. β2-glycoprotein I (β2GPI) has been considered as the actual target antigen for anti-CL antibodies. This study investigates the association of periodontal infection with anti-CL antibodies in patients with SLE. Methods: Fifty-three SLE female patients and 56 healthy female volunteers were recruited in this case-control study. All participants received periodontal examinations. The presence of Porphyromonas gingivalis and Treponema denticola in saliva and plaque samples was detected by polymerase chain reaction. Levels of serum anti-CL and anti-β2GPI antibodies were examined using enzyme-linked immunosorbent assay. Results: Patients with SLE exhibited more periodontal attachment loss and increased titers of serum anti-CL and anti-β2GPI antibodies compared with healthy controls. Patients with active SLE who harbored P. gingivalis or P. gingivalis together with T. denticola intraorally exhibited significantly higher anti-CL and anti-β2GPI antibodies than those without these bacteria. Anti-CL and anti-β2GPI antibody levels correlated positively with clinical attachment level. Furthermore, increased anti-β2GPI antibody levels were significantly associated with C-reactive protein and erythrocyte sedimentation rate. Conclusions: Elevated anti-CL and anti-β2GPI antibody levels were associated with periodontopathic bacteria and periodontal breakdown in patients with SLE. Periodontitis might be a modifiable risk factor for SLE.
SDGs
Other Subjects
beta2 glycoprotein 1; C reactive protein; cardiolipin antibody; creatinine; adult; aged; blood; case control study; classification; cohort analysis; comparative study; erythrocyte sedimentation rate; female; human; immunology; microbiology; middle aged; periodontal disease; periodontal index; periodontal pocket; periodontitis; Porphyromonas gingivalis; saliva; systemic lupus erythematosus; thrombocyte count; tooth plaque; Treponema denticola; Adult; Aged; Antibodies, Anticardiolipin; beta 2-Glycoprotein I; Blood Sedimentation; C-Reactive Protein; Case-Control Studies; Cohort Studies; Creatinine; Dental Plaque; Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Platelet Count; Porphyromonas gingivalis; Saliva; Treponema denticola
Publisher
American Academy of Periodontology
Type
journal article