https://scholars.lib.ntu.edu.tw/handle/123456789/545837
標題: | Association between neovascular age-related macular degeneration and dementia: A population-based case-control study in Taiwan | 作者: | Chung S.-D. Lee, Cha-Ze Kao L.-T. Lin H.-C. Tsai M.-C. Sheu J.-J. |
公開日期: | 2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 3 | 來源出版物: | PLoS ONE | 摘要: | Most available studies focusing on the association between neovascular age-related macular degeneration (AMD) and dementia have conflicting results. This study aimed to investigate the association between previously diagnosed AMD and dementia using a populationbased dataset in Taiwan. Methods Data for this case-control study were retrospectively collected from the Taiwan National Health Insurance Research Database. We identified 13,402 subjects who had a diagnosis of dementia as cases, and 40,206 subjects without dementia as controls. A conditional logistic regression was used to examine the association of dementia with previously diagnosed neovascular AMD. Results We found that of the study sample of 53,608 subjects, 1.01% had previously diagnosed neovascular AMD, 1.35%and 0.90% for cases and the controls, respectively (p<0.001). The conditional logistic regression analysis suggested that the odds ratio of prior neovascular AMD for cases was 1.37 (95% confidence interval: 1.14?1.65) compared to the controls after adjusting for subjects' age, monthly income, geographic location, urbanization level, and hyperlipidemia, diabetes, hypertension, stroke, ischemic heart disease, and whether or not a subjects underwent cataract surgery prior to index date than controls. Conclusions Dementia subjects were associated with a higher proportion of prior neovascular AMD than were the controls. ? 2015 Chung et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924207417&doi=10.1371%2fjournal.pone.0120003&partnerID=40&md5=e508e9282e9446a8d9cf3f067231c6ab https://scholars.lib.ntu.edu.tw/handle/123456789/545837 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0120003 | SDG/關鍵字: | adult; age; age related macular degeneration; aged; Article; cataract extraction; cerebrovascular accident; controlled study; dementia; diabetes mellitus; disease association; female; geography; human; hyperlipidemia; hypertension; income; ischemic heart disease; logistic regression analysis; major clinical study; male; middle aged; population based case control study; retrospective study; risk assessment; Taiwan; urbanization; very elderly; clinical trial; dementia; factual database; macular degeneration; multicenter study; randomized controlled trial; register; Retinal Neovascularization; Adult; Aged; Aged, 80 and over; Databases, Factual; Dementia; Female; Humans; Macular Degeneration; Male; Middle Aged; Registries; Retinal Neovascularization; Taiwan |
顯示於: | 醫學系 |
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