Association between neovascular age-related macular degeneration and dementia: A population-based case-control study in Taiwan
Journal
PLoS ONE
Journal Volume
10
Journal Issue
3
Date Issued
2015
Author(s)
Abstract
Most available studies focusing on the association between neovascular age-related macular degeneration (AMD) and dementia have conflicting results. This study aimed to investigate the association between previously diagnosed AMD and dementia using a populationbased dataset in Taiwan. Methods Data for this case-control study were retrospectively collected from the Taiwan National Health Insurance Research Database. We identified 13,402 subjects who had a diagnosis of dementia as cases, and 40,206 subjects without dementia as controls. A conditional logistic regression was used to examine the association of dementia with previously diagnosed neovascular AMD. Results We found that of the study sample of 53,608 subjects, 1.01% had previously diagnosed neovascular AMD, 1.35%and 0.90% for cases and the controls, respectively (p<0.001). The conditional logistic regression analysis suggested that the odds ratio of prior neovascular AMD for cases was 1.37 (95% confidence interval: 1.14?1.65) compared to the controls after adjusting for subjects' age, monthly income, geographic location, urbanization level, and hyperlipidemia, diabetes, hypertension, stroke, ischemic heart disease, and whether or not a subjects underwent cataract surgery prior to index date than controls. Conclusions Dementia subjects were associated with a higher proportion of prior neovascular AMD than were the controls. ? 2015 Chung et al.
Other Subjects
adult; age; age related macular degeneration; aged; Article; cataract extraction; cerebrovascular accident; controlled study; dementia; diabetes mellitus; disease association; female; geography; human; hyperlipidemia; hypertension; income; ischemic heart disease; logistic regression analysis; major clinical study; male; middle aged; population based case control study; retrospective study; risk assessment; Taiwan; urbanization; very elderly; clinical trial; dementia; factual database; macular degeneration; multicenter study; randomized controlled trial; register; Retinal Neovascularization; Adult; Aged; Aged, 80 and over; Databases, Factual; Dementia; Female; Humans; Macular Degeneration; Male; Middle Aged; Registries; Retinal Neovascularization; Taiwan
Publisher
Public Library of Science
Type
journal article