https://scholars.lib.ntu.edu.tw/handle/123456789/546381
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Y.-L. | en_US |
dc.contributor.author | Chen, I.-H. | en_US |
dc.contributor.author | Shen, K.-Y. | en_US |
dc.contributor.author | Huang, R.-Y. | en_US |
dc.contributor.author | Wang, W.-R. | en_US |
dc.contributor.author | Chou, C.-J. | en_US |
dc.contributor.author | Chang, T.-T. | en_US |
dc.contributor.author | Chu, C.-L. | en_US |
dc.date.accessioned | 2021-02-03T15:57:06Z | - |
dc.date.available | 2021-02-03T15:57:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 00142980 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/546381 | - |
dc.description.abstract | Dendritic cells (DC) play a central role in the initiation and regulation of immune responses. Increasing evidence has indicated that manipulation of DC can serve as a therapeutic mechanism for immunomodulation. In this study we tested some unique compounds isolated from Antrodia cinnamomea, a medicinal fungus in Taiwan, on mouse bone marrow-derived DC activation. A triterpenoid methyl antcinate K (me-AntK) promoted DC maturation by enhancing the expression of MHC class II, CD86, and reducing the endocytosis. TNF-alpha, MCP-1, and MIP-1beta were secreted by DC after me-AntK treatment, indicating augmentation of innate immunity by me-AntK. Interestingly, the me-AntK-activated DC induced Ag-specific T-cell proliferation and facilitated Th2 differentiation. Examining signaling responses, we found that me-AntK treatment uniquely activated JNK and ERK in DC. Our results demonstrate that me-AntK is the first natural triterpenoid to promote the ability of DC to prime Th2 responses. This suggests that me-AntK can potentially be applied to enhance immune responses and modulate DC function in immunotherapy. | en_US |
dc.language.iso | animation | en_US |
dc.publisher | WILEY | en_US |
dc.relation.ispartof | European Journal of Immunology | en_US |
dc.subject | URSOLIC ACID; NATURAL-PRODUCTS; IMMUNE-RESPONSE; IFN-GAMMA; T-CELLS; IN-VIVO; SP-NOV; CAMPHORATA; MATURATION; MACROPHAGES | en_US |
dc.title | A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/eji.200839039 | - |
dc.identifier.pmid | 19701888 | - |
dc.identifier.scopus | 2-s2.0-70349232883 | - |
dc.identifier.isi | WOS:000269786000021 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?eid=2-s2.0-70349232883&partnerID=MN8TOARS | - |
dc.relation.pages | 2482 | en_US |
dc.relation.journalvolume | 39 | en_US |
dc.relation.journalissue | 9 | en_US |
dc.identifier.external | 19179452 | - |
dc.relation.pageend | 2491 | en_US |
item.grantfulltext | none | - |
item.languageiso639-1 | animation | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | 免疫學研究所 |
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