https://scholars.lib.ntu.edu.tw/handle/123456789/546381
Title: | A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation | Authors: | Yu, Y.-L. Chen, I.-H. Shen, K.-Y. Huang, R.-Y. Wang, W.-R. Chou, C.-J. Chang, T.-T. Chu, C.-L. |
Keywords: | URSOLIC ACID; NATURAL-PRODUCTS; IMMUNE-RESPONSE; IFN-GAMMA; T-CELLS; IN-VIVO; SP-NOV; CAMPHORATA; MATURATION; MACROPHAGES | Issue Date: | 2009 | Publisher: | WILEY | Journal Volume: | 39 | Journal Issue: | 9 | Start page/Pages: | 2482 | Source: | European Journal of Immunology | Abstract: | Dendritic cells (DC) play a central role in the initiation and regulation of immune responses. Increasing evidence has indicated that manipulation of DC can serve as a therapeutic mechanism for immunomodulation. In this study we tested some unique compounds isolated from Antrodia cinnamomea, a medicinal fungus in Taiwan, on mouse bone marrow-derived DC activation. A triterpenoid methyl antcinate K (me-AntK) promoted DC maturation by enhancing the expression of MHC class II, CD86, and reducing the endocytosis. TNF-alpha, MCP-1, and MIP-1beta were secreted by DC after me-AntK treatment, indicating augmentation of innate immunity by me-AntK. Interestingly, the me-AntK-activated DC induced Ag-specific T-cell proliferation and facilitated Th2 differentiation. Examining signaling responses, we found that me-AntK treatment uniquely activated JNK and ERK in DC. Our results demonstrate that me-AntK is the first natural triterpenoid to promote the ability of DC to prime Th2 responses. This suggests that me-AntK can potentially be applied to enhance immune responses and modulate DC function in immunotherapy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/546381 | ISSN: | 00142980 | DOI: | 10.1002/eji.200839039 |
Appears in Collections: | 免疫學研究所 |
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