https://scholars.lib.ntu.edu.tw/handle/123456789/547694
標題: | A Benzenoid 4,7-Dimethoxy-5-Methyl-L, 3-Benzodioxole from Antrodia cinnamomea Attenuates Dendritic Cell-Mediated Th2 Allergic Responses | 作者: | You, Ren In Lee, Yi Pang Su, Ting Yi Lin, Chi Chien Chen, Chang Shan CHING-LIANG CHU |
關鍵字: | Antrodia cinnamomea | Cholera Toxin | Dendritic Cell | Food Allergy | Th2;Antrodia cinnamomea; Cholera Toxin; Dendritic Cell; Food Allergy; Th2 | 公開日期: | 1-一月-2019 | 出版社: | WORLD SCIENTIFIC PUBL CO PTE LTD | 卷: | 47 | 期: | 6 | 起(迄)頁: | 1271 | 來源出版物: | American Journal of Chinese Medicine | 摘要: | © 2019 World Scientific Publishing Company. Dendritic cells (DCs) play a critical role in initiating immune responses; however, DCs also induce Th2-related allergic sensitivities. Thus, DCs become a target for therapeutic design in allergic diseases. In this study, we aim to investigate the anti-allergic effect of pure compounds from a medicinal mushroom Antrodia cinnamomea (Ac) on DC-induced allergic responses. We identified a benzenoid compound 4,7-dimethoxy-5-methyl-l,3-benzodioxole (DMB) which may modulate Th2 polarization in bone marrow-derived DCs (BMDCs) and in a murine food allergy model. DMB effectively reduced the Th2 adjuvant cholera toxin (CT)-induced BMDC maturation and cytokine production. In studying the mechanism, DMB blocked the molecular processes involved in Th2 induction, including cAMP activation, IL-33 production, and IRF4/Tim4 upregulation, in CT-activated BMDCs. Furthermore, DMB treatment attenuated the symptoms, clinical scores, and Th2 responses of CT-induced ovalbumin (OVA)-specific food allergy in mice at sensitization stage. These results indicated that DMB could suppress DC function for Th2 polarization and mitigate allergic responses. Thus, DMB may have potential to be a novel agent for preventing or treating food allergy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/547694 | ISSN: | 0192415X | DOI: | 10.1142/S0192415X19500654 | SDG/關鍵字: | 4,7 dimethoxy 5 methyl levo,3 benzodioxole; antiallergic agent; aromatic compound; cholera toxin; cyclic AMP; interferon regulatory factor 4; interleukin 33; ovalbumin; plant extract; unclassified drug; 1,3 benzodioxole derivative; antiallergic agent; cytokine; animal cell; animal experiment; animal model; antiallergic activity; Antrodia camphorata; Article; bone marrow derived dendritic cell; cell maturation; controlled study; cytokine production; drug isolation; drug mechanism; drug synthesis; food allergy; in vitro study; in vivo study; mouse; nonhuman; polarization; sensitization; Th2 cell; upregulation; animal; Antrodia; Bagg albino mouse; cell culture; chemistry; dendritic cell; disease model; food allergy; hypersensitivity; immunology; metabolism; phytotherapy; Th2 cell; Animals; Anti-Allergic Agents; Antrodia; Benzodioxoles; Cells, Cultured; Cytokines; Dendritic Cells; Disease Models, Animal; Food Hypersensitivity; Hypersensitivity; Mice, Inbred BALB C; Ovalbumin; Phytotherapy; Th2 Cells |
顯示於: | 免疫學研究所 |
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