https://scholars.lib.ntu.edu.tw/handle/123456789/553202
Title: | Hypocalcemia and tetany caused by vitamin D deficiency in a child with intestinal lymphangiectasia | Authors: | Lu Y.-Y. JIA-FENG WU YEN-HSUAN NI STEVEN SHINN-FORNG PENG CHIA-TUNG SHUN MEI-HWEI CHANG |
Issue Date: | 2009 | Journal Volume: | 108 | Journal Issue: | 10 | Start page/Pages: | 814-818 | Source: | Journal of the Formosan Medical Association | Abstract: | Primary intestinal lymphangiectasia is a rare disease of children, which is characterized by chronic diarrhea and complicated with malnutrition, including fat-soluble vitamin deficiency. We report a girl aged 4 years and 8 months who was diagnosed with the disease by endoscopic duodenal biopsy at 8 months of age. She presented initially with chronic diarrhea at 4 months of age. Generalized edema with hypoalbuminemia frequently occurred despite regular albumin supplements. Multiple vitamins initially were not supplied regularly. Episodes of tetany caused by hypocalcemia developed 4 years after the diagnosis of intestinal lymphangiectasia. Imaging study (long-bone X-ray and dual-energy X-ray absorptiometry) revealed low bone density. Complicated vitamin D deficiency [low serum 25-hydroxy vitamin D concentration (< 12.48 mmol/L, the detection limit)] and secondary hyperparathyroidism were confirmed via blood testing. Vitamin D supplementation for 3 months improved her bone density, secondary hyperparathyroidism and frequent tetany. Vitamin D status should be monitored in patients with intestinal lymphangiectasia. ?2009 Elsevier & Formosan Medical Association. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/553202 | ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60410-1 | SDG/Keyword: | vitamin D; article; biopsy; bone density; case report; diet supplementation; drug effect; duodenoscopy; female; human; hypocalcemia; intestine lymphangiectasia; pathology; pathophysiology; photon absorptiometry; preschool child; protein losing gastroenteropathy; secondary hyperparathyroidism; tetany; treatment outcome; vitamin D deficiency; Absorptiometry, Photon; Biopsy; Bone Density; Child, Preschool; Dietary Supplements; Duodenoscopy; Female; Humans; Hyperparathyroidism, Secondary; Hypocalcemia; Lymphangiectasis, Intestinal; Protein-Losing Enteropathies; Tetany; Treatment Outcome; Vitamin D; Vitamin D Deficiency |
Appears in Collections: | 法醫學科所 |
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