https://scholars.lib.ntu.edu.tw/handle/123456789/557569
Title: | Prominent proliferative response of peripheral blood mononuclear cells to a recombinant non-structural (NS3) protein of hepatitis C virus in patients with chronic hepatitis C | Authors: | PEI-MING YANG Hwang L.-H. Lai M.-Y. Huang W.-L. Chu Y.-D. Chi W.-K. BOR-LUEN CHIANG JIA-HORNG KAO PEI-JER CHEN DING-SHINN CHEN |
Issue Date: | 1995 | Publisher: | Blackwell Publishing Ltd | Journal Volume: | 101 | Journal Issue: | 2 | Start page/Pages: | 272-277 | Source: | Clinical and Experimental Immunology | Abstract: | The proliferative response of peripheral blood mononuclear cells (PBMC) to a recombinant nonstructural (NS3) protein of hepatitis C virus (HCV) was studied in 41 patients with chronic hepatitis C. Of them, 28 had chronic persistent hepatitis (CPH) and 13 chronic active hepatitis (CAH). The positive proliferation rate of PBMC to the recombinant NS3 protein, T9Ag, was 66% in the 41 patients (77% in CAH versus 61% in CPH; P > 0.05) when stimulation index (SI) = 4 was set as the cut-off value. However, mean SI of CAH patients was significantly higher than that of CPH patients (8.3 ± 5.2 versus 5.1 ± 3.6; P < 0.05). Six other chronic hepatitis patients who were repeatedly negative for anti-HCV antibody but positive for serum HCV RNA also had an SI of ? 4.0. The frequency of cellular immune response to the T9Ag is among the highest results obtained by using HCV antigens tested so far. Our studies thus indicate that NS3 is an immunologically important region of HCV for T cells. Moreover, the proliferative response to T9Ag may help to establish hepatitis C etiology in chronic hepatitis patients who are seronegative with currently available anti-HCV assays. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984589074&doi=10.1111%2fj.1365-2249.1995.tb08350.x&partnerID=40&md5=5d29393c4f9d719e50d1966a499432e8 https://scholars.lib.ntu.edu.tw/handle/123456789/557569 |
ISSN: | 0009-9104 | DOI: | 10.1111/j.1365-2249.1995.tb08350.x | SDG/Keyword: | recombinant protein; virus protein; adult; article; chronic active hepatitis; clinical article; controlled study; female; hepatitis C; Hepatitis C virus; human; lymphocyte proliferation; male; priority journal; T lymphocyte |
Appears in Collections: | 醫學系 |
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