https://scholars.lib.ntu.edu.tw/handle/123456789/558384
標題: | No association between plasma adiponectin levels and central auditory function in adults | 作者: | Hwang, Juen-Haur FEN-YU TSENG TIEN-CHEN LIU WEI-SHIUNG YANG |
關鍵字: | Adiponectin | Age-related hearing impairment | Central auditory function | Pitch pattern sequence | Plasma;Adiponectin; Age-related hearing impairment; Central auditory function; Pitch pattern sequence; Plasma | 公開日期: | 二月-2015 | 卷: | 30 | 期: | 1 | 來源出版物: | Metabolic brain disease | 摘要: | Adiponectin might play a protective role in cardiometabolic and peripheral auditory disorders, but its role on central auditory function was still unclear. The aim of this study was to examine whether there is an association between plasma adiponectin levels and central auditory function in adults. We recruited 297 adults, with normal or symmetrical sensorineural hearing loss and normal cognitive functions. Multivariate linear regression was performed to assess the association between plasma adiponectin concentrations and pitch pattern sequence (PPS) score, which was one of central auditory tests. The results showed that there were 224 (75.4%) women and 73 (24.6%) men in this study. The mean age was 58.1 ± 8.4 years, the mean waist circumference (WC) was 81.1 ± 8.3 cm, and the mean body mass index (BMI) was 24.0 ± 3.0 kg/m(2). The mean PPS score was 71.5 ± 14.1%, and plasma adiponectin concentration was 12.7 ± 5.5 g/mL. After adjusting for age, gender, WC, coronary artery disease, hypertension, diabetes mellitus, chronic kidney disease, smoking and drinking, plasma adiponectin concentrations (coefficient ± standard error, β ± SE = -0.09 ± 0.16, p = 0.563) were found to have no significant associations with PPS score. When WC was excluded from these variables in the multivariate linear regression model, plasma adiponectin concentrations (β ± SE = -0.03 ± 0.15, p = 0.855) were still not significantly associated with PPS score. In conclusion, plasma adiponectin levels were not significantly associated with PPS score, which was one of central auditory function tests. More studies should be conducted for the underlying mechanisms of obesity-related central auditory dysfunction. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/558384 | ISSN: | 08857490 | DOI: | 10.1007/s11011-014-9597-1 | SDG/關鍵字: | adiponectin; ADIPOQ protein, human; aged; blood; body mass; comorbidity; Coronary Disease; diabetes mellitus; drinking behavior; Dyslipidemias; female; hearing; Hearing Loss, Sensorineural; human; hypertension; Kidney Diseases; male; middle aged; pure tone audiometry; risk factor; smoking; waist circumference; Adiponectin; Aged; Alcohol Drinking; Audiometry, Pure-Tone; Body Mass Index; Comorbidity; Coronary Disease; Diabetes Mellitus; Dyslipidemias; Female; Hearing Loss, Sensorineural; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Pitch Perception; Risk Factors; Smoking; Waist Circumference |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。