No association between plasma adiponectin levels and central auditory function in adults
Journal
Metabolic brain disease
Journal Volume
30
Journal Issue
1
Date Issued
2015-02
Author(s)
Abstract
Adiponectin might play a protective role in cardiometabolic and peripheral auditory disorders, but its role on central auditory function was still unclear. The aim of this study was to examine whether there is an association between plasma adiponectin levels and central auditory function in adults. We recruited 297 adults, with normal or symmetrical sensorineural hearing loss and normal cognitive functions. Multivariate linear regression was performed to assess the association between plasma adiponectin concentrations and pitch pattern sequence (PPS) score, which was one of central auditory tests. The results showed that there were 224 (75.4%) women and 73 (24.6%) men in this study. The mean age was 58.1 ± 8.4 years, the mean waist circumference (WC) was 81.1 ± 8.3 cm, and the mean body mass index (BMI) was 24.0 ± 3.0 kg/m(2). The mean PPS score was 71.5 ± 14.1%, and plasma adiponectin concentration was 12.7 ± 5.5 g/mL. After adjusting for age, gender, WC, coronary artery disease, hypertension, diabetes mellitus, chronic kidney disease, smoking and drinking, plasma adiponectin concentrations (coefficient ± standard error, β ± SE = -0.09 ± 0.16, p = 0.563) were found to have no significant associations with PPS score. When WC was excluded from these variables in the multivariate linear regression model, plasma adiponectin concentrations (β ± SE = -0.03 ± 0.15, p = 0.855) were still not significantly associated with PPS score. In conclusion, plasma adiponectin levels were not significantly associated with PPS score, which was one of central auditory function tests. More studies should be conducted for the underlying mechanisms of obesity-related central auditory dysfunction.
Subjects
Adiponectin | Age-related hearing impairment | Central auditory function | Pitch pattern sequence | Plasma
Adiponectin; Age-related hearing impairment; Central auditory function; Pitch pattern sequence; Plasma
Other Subjects
adiponectin; ADIPOQ protein, human; aged; blood; body mass; comorbidity; Coronary Disease; diabetes mellitus; drinking behavior; Dyslipidemias; female; hearing; Hearing Loss, Sensorineural; human; hypertension; Kidney Diseases; male; middle aged; pure tone audiometry; risk factor; smoking; waist circumference; Adiponectin; Aged; Alcohol Drinking; Audiometry, Pure-Tone; Body Mass Index; Comorbidity; Coronary Disease; Diabetes Mellitus; Dyslipidemias; Female; Hearing Loss, Sensorineural; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Pitch Perception; Risk Factors; Smoking; Waist Circumference
Type
journal article