https://scholars.lib.ntu.edu.tw/handle/123456789/558397
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JENNY LING-YU CHEN | en_US |
dc.contributor.author | Tsai Y.-C. | en_US |
dc.contributor.author | Tsai M.-H. | en_US |
dc.contributor.author | Lee S.-Y. | en_US |
dc.contributor.author | Wei M.-F. | en_US |
dc.contributor.author | SUNG-HSIN KUO | en_US |
dc.contributor.author | MING-JIUM SHIEH | en_US |
dc.creator | Jenny Ling-Yu Chen;Tsai Y.-C.;Tsai M.-H.;Lee S.-Y.;Wei M.-F.;Kuo S.-H.;Shieh M.-J. | - |
dc.date.accessioned | 2021-04-30T07:26:53Z | - |
dc.date.available | 2021-04-30T07:26:53Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0934-0866 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/558397 | - |
dc.description.abstract | Resistance of cancer stem cells to radiotherapy remains a major obstacle to successful cancer management. Prominin-1 (PROM1) is a cancer stem cell marker. Nanoparticle (NP) chemotherapeutics preferentially accumulate in tumors and are able to target cancer and cancer stem-like cells through cancer cell-specific ligands, making them uniquely suited as radiosensitizers for chemoradiation therapy. Using a biocompatible apoferritin NP, a PROM1-targeted NP carrying irinotecan (PROM1-NP) is engineered. The synergistic effect of the NP and irradiation is evaluated in PROM1-overexpressing HCT-116 colorectal cancer cell lines in vitro and in vivo. PROM1-NP has a size of 17.2 ± 0.2 nm and surface charge of ?13.5 ± 0.2 mV. It demonstrates higher intracellular uptake than nontargeted NP or irinotecan alone. Treatment with PROM1-NPs decreases HCT-116 cell proliferation in a dose- and time-dependent manner. In vitro radiosensitization reveals that PROM1-NP is significantly more effective as a radiosensitizer than nontargeted NP or irinotecan. HCT-116 tumor xenograft growth is markedly slower following treatment with PROM1-NP plus irradiation, suggesting that PROM1-NP is more effective as a radiosensitizer than irinotecan and nontargeted NP in vivo. This study provides the first preclinical evidence of the effectiveness of PROM1-targeted NP formulation of irinotecan as a radiosensitizer. ? 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.relation.ispartof | Particle and Particle Systems Characterization | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Biocompatibility; Cell culture; Cell proliferation; Cells; Cytology; Irradiation; Nanoparticles; Stem cells; Tumors; Apoferritin; Chemoradiation therapies; Colorectal cancer; Colorectal cancer cell; Intracellular uptake; Irinotecan; Radio-sensitization; Synergistic effect; Diseases | - |
dc.title | Prominin-1-Specific Binding Peptide-Modified Apoferritin Nanoparticle Carrying Irinotecan as a Novel Radiosensitizer for Colorectal Cancer Stem-Like Cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/ppsc.201600424 | - |
dc.identifier.scopus | 2-s2.0-85014077314 | - |
dc.relation.journalvolume | 34 | - |
dc.relation.journalissue | 5 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Radiology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Radiation Oncology-NTUCC | - |
crisitem.author.dept | Division of Radiation Oncology | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | School of Medicine | - |
crisitem.author.orcid | 0000-0001-8553-8069 | - |
crisitem.author.orcid | 0000-0003-0054-887X | - |
crisitem.author.orcid | 0000-0003-2921-4443 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | Oncology-NTUH | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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