https://scholars.lib.ntu.edu.tw/handle/123456789/559125
標題: | Recent advancements in microfluidics that integrate electrical sensors for whole blood analysis | 作者: | Kuan, D.-H. Huang, N.-T. NIEN-TSU HUANG |
公開日期: | 2020 | 卷: | 12 | 期: | 26 | 起(迄)頁: | 3318-3332 | 來源出版物: | Analytical Methods | 摘要: | Whole blood analysis reveals crucial information about various physiological and pathological conditions, including cancer metastasis, infection, and immune status, among others. Despite this rich information, the complex composition of whole blood usually required multiple sample preparation steps to purify targeted analytes. Traditionally, whole blood preparation processes, including centrifugation, lysis, dilution, or staining, are usually manually operated by well-trained technicians using bench-top instruments. This preparation can require a large blood volume and cannot be directly integrated with detection systems. Recently, various studies have integrated microfluidics with electrical sensors for whole blood analysis, with a focus on cell-based analysis, such as cell type, number, morphology, phenotype, and secreted molecules. These miniaturized systems require less sample and shorter reaction times. Besides, the sample processing and analysis can be fully integrated and automated with minimal operations. We believe these systems can transfer the current whole blood analysis from hospitals or laboratories into clinics or home settings to enable real-time and continuous health condition monitoring in point-of-care settings. ? 2020 The Royal Society of Chemistry. |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85091051826&partnerID=40&md5=9051d4effaf4ad27f7597aec02483ab6 https://scholars.lib.ntu.edu.tw/handle/123456789/559125 |
DOI: | 10.1039/d0ay00413h | SDG/關鍵字: | Condition monitoring; Continuous time systems; Diseases; Home health care; Microfluidics; Real time systems; Cancer metastasis; Complex compositions; Electrical sensors; Integrated microfluidics; Miniaturized systems; Pathological conditions; Preparation process; Secreted molecules; Blood; blood examination; centrifugation; microfluidics; point of care system; specimen handling; Centrifugation; Hematologic Tests; Microfluidics; Point-of-Care Systems; Specimen Handling |
顯示於: | 電機工程學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。