https://scholars.lib.ntu.edu.tw/handle/123456789/561963
標題: | Increased heterogeneity of brain perfusion predicts the development of cerebrovascular accidents | 作者: | Lin T.-S. Hsu P.-Y. CHI-LUN KO YU-MIN KUO CHENG-HSUN LU CHIEH-YU SHEN SONG-CHOU HSIEH |
公開日期: | 2021 | 卷: | 100 | 期: | 15 | 來源出版物: | Medicine | 摘要: | ABSTRACT: The heterogeneity of brain perfusion is related to the risk factors of thromboembolic events such as antiphospholipid syndrome. However, the effectiveness of brain perfusion heterogeneity as a marker to predict thromboembolic events has not been confirmed. Our objective was to evaluate the effectiveness of brain perfusion heterogeneity as a marker to predict the development of cerebrovascular accidents. In this retrospective cohort study, patients who underwent Tc-99m ECD brain SPECT from January 1, 2006 through December 31, 2008 were included. Each study was reoriented with the Talairach space provided by the NeuroGam Software package. Heterogeneity of brain perfusion was measured as the coefficient of variation. The study outcome was the risk of cerebral vascular accidents in patients with increased heterogeneity of brain perfusion between January 1, 2006 and December 31, 2015. A multiple Cox proportional hazards model was applied to evaluate the risk of cerebrovascular accidents. A total of 70 patients were included in this study. The median age was 39 years (range, 28 - 59 years). There were 55 (78.6%) women. For increased heterogeneity of brain perfusion, the hazard ratio of cerebrovascular accidents was 2.68 (95% CI, 1.41 - 5.09; P?=?.003) after adjusting for age, sex, hypertension, diabetes mellitus, and dyslipidemia. Our study suggests that increased heterogeneity of brain perfusion is associated with an increased risk of cerebrovascular accidents. Copyright ? 2021 the Author(s). Published by Wolters Kluwer Health, Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/561963 | ISSN: | 1536-5964 | DOI: | 10.1097/MD.0000000000025557 | SDG/關鍵字: | biological marker; cysteine; cysteine ethyl ester tc 99m; radiopharmaceutical agent; technetium complex; adult; brain; brain circulation; cerebrovascular accident; diagnostic imaging; female; human; male; middle aged; pathophysiology; predictive value; procedures; proportional hazards model; retrospective study; risk assessment; single photon emission computed tomography; Adult; Biomarkers; Brain; Cerebrovascular Circulation; Cysteine; Female; Heart Disease Risk Factors; Humans; Male; Middle Aged; Organotechnetium Compounds; Predictive Value of Tests; Proportional Hazards Models; Radiopharmaceuticals; Retrospective Studies; Risk Assessment; Stroke; Tomography, Emission-Computed, Single-Photon |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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