https://scholars.lib.ntu.edu.tw/handle/123456789/563360
Title: | Association of hepatitis C virus infection and malnutrition-inflammation complex syndrome in maintenance hemodialysis patients | Authors: | Tsai H.-B. PAU-CHUNG CHEN CHEN-HUA LIU Hung P.-H. Chen M.-T. CHIH-KANG CHIANG JIA-HORNG KAO KUAN-YU HUNG |
Issue Date: | 2012 | Journal Volume: | 27 | Journal Issue: | 3 | Start page/Pages: | 1176-1183 | Source: | Nephrology Dialysis Transplantation | Abstract: | Background. Patients undergoing maintenance hemodialysis (MHD) have a significantly higher prevalence of hepatitis C virus (HCV) infection and malnutrition-inflammation complex syndrome (MICS). In the present study of Taiwanese MHD patients, we determined the clinical characteristics and influence of HCV infection on MICS by calculation of the malnutrition-inflammation score (MIS). Methods. This was a prospective longitudinal study performed at a single hemodialysis (HD) center in Taiwan from September 2007 through March 2008. The study enrolled 58 patients (38%) in the active HCV group and 95 patients (62%) in the non-HCV group. The two or three weekly HD sessions of all patients were followed for 7 months. The MIS was assessed using 10 components, 7 from the conventional subjective global assessment of nutrition and 3 additional elements, body mass index, serum albumin and total iron-binding capacity. Results. HD vintage and total MIS score were greater in patients with active HCV. The active HCV group had significantly longer dialysis vintage and lower total cholesterol but higher total MIS score than the non-HCV group. The MIS 5 score, a measure of major comorbid conditions (including number of years on dialysis), was also significantly higher in the active HCV group. Conclusion. MHD patients with active HCV infections have more severe MICS-associated metabolic and physiological disease than MHD patients without active HCV infection. ? 2011 The Author. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861121774&doi=10.1093%2fndt%2fgfr458&partnerID=40&md5=38f39e62a643a0165a4a348dbcc0ffb9 https://scholars.lib.ntu.edu.tw/handle/123456789/563360 |
ISSN: | 0931-0509 | DOI: | 10.1093/ndt/gfr458 | SDG/Keyword: | albumin; cholesterol; adult; aged; albumin blood level; article; body mass; cholesterol blood level; clinical assessment; clinical feature; comorbidity; controlled clinical trial; controlled study; disease association; disease severity; ethnic group; female; hemodialysis; hepatitis C; human; infection rate; infection risk; iron binding capacity; maintenance therapy; major clinical study; male; malnutrition inflammation complex syndrome; outcome assessment; priority journal; protein calorie malnutrition; risk assessment; scoring system; Taiwan; treatment duration; viral clearance; virus load; Aged; Body Mass Index; C-Reactive Protein; Female; Hepacivirus; Hepatitis C; Humans; Inflammation; Kidney Failure, Chronic; Longitudinal Studies; Male; Malnutrition; Middle Aged; Nutritional Status; Polymerase Chain Reaction; Prognosis; Prospective Studies; Protein-Energy Malnutrition; Renal Dialysis; RNA, Viral; Survival Rate; Taiwan |
Appears in Collections: | 毒理學研究所 |
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