https://scholars.lib.ntu.edu.tw/handle/123456789/564809
標題: | Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis | 作者: | Chen C.-N. Hsiao C.-J. SHOEI-SHENG LEE JIH-HWA GUH Chiang P.-C. Huang C.-C. Huang W.-J. |
公開日期: | 2012 | 卷: | 26 | 期: | 2 | 起(迄)頁: | 116-124 | 來源出版物: | Natural Product Research | 摘要: | Our previous studies demonstrated that eight prenylated flavanones (1-8), isolated from Taiwanese propolis, were capable of a broad spectrum of biological activities. Among them, nymphaeol A (3), nymphaeol B (4) and nymphaeol C (7), abundant in Taiwanese propolis, exhibited cytotoxicity against cancer cell lines. It therefore seemed interesting to improve their activity via a semi-synthetic strategy. In this study, 12 novel prenylated flavanones were synthesised in our laboratory and their activities were assessed for two human prostate cancer cell lines, PC-3 and DU-145, and a human hepatoma cell line, Hep-3B. Of these compounds, 10c, 11 and 12 showed more potent cytotoxicity against the PC-3 cell line than 5-Fu. Using cytometric analysis followed by double staining with annexin V-FITC and propidium iodide, it was observed that these compounds induced apoptosis as well. This suggests that prenylated flavanones 10c, 11 and 12 may have anticancer potential for further development. ? 2012 Copyright Taylor and Francis Group, LLC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863064594&doi=10.1080%2f14786419.2010.535146&partnerID=40&md5=c424143a51a0a677b1f0b2ece7f44b41 https://scholars.lib.ntu.edu.tw/handle/123456789/564809 |
ISSN: | 14786419 | DOI: | 10.1080/14786419.2010.535146 | SDG/關鍵字: | 2',6 di(2 carboxylethyl) 3',4',5,7 tetramethoxyflavanone; 2',6 di(2 oxo ethyl) 3',4',5,7 tetramethoxyflavanone; 3 (3 hydroxy 3 methylbutyl) 2' (7 hydroxy 3,7 dimethyloct 3 enyl) 6 hydroxy 3',4',2,4 tetramethoxychalcone; 3',4',7 o trimethylnymphaeol c; 6 (3 hydroxy 3 methylbutyl) 2' (7 hydroxy 3,7 dimethyloctyl) 3',4',5,7 tetramethoxyflavanon; annexin; antineoplastic agent; flavone derivative; nymphaeol a; nymphaeol b; nymphaeol c; propidium iodide; propolis; unclassified drug; antineoplastic activity; apoptosis; article; cancer cell; chemical modification; controlled study; cytometry; human; human cell; liver cell carcinoma; prostate cancer; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Discovery; Flavanones; Flow Cytometry; Humans; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Prenylation; Propolis; Prostatic Neoplasms; Taiwan |
顯示於: | 藥學系 |
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