https://scholars.lib.ntu.edu.tw/handle/123456789/564864
Title: | Two new sesquiterpene lactones from Ixeris chinensis | Authors: | Khalil A.T. Shen Y.-C. JIH-HWA GUH Cheng S.-Y. |
Keywords: | Asteraceae; Cytotoxic activity; Guaianolide; Ixeris chinensis; Ixerochinolide; Ixerochinoside | Issue Date: | 2005 | Journal Volume: | 53 | Journal Issue: | 1 | Start page/Pages: | 15-17 | Source: | Chemical and Pharmaceutical Bulletin | Abstract: | Phytochemical investigation of Ixeris chinensis NAKAI (Asteraceae) has resulted in the isolation of a new guaianolide-type sesquiterpene lactone, ixerochinolide (1) as well as the related glucoside, ixerochinoside (2). In addition, the known guaianolides, 8βhydroxy-3-oxo-guaia-4(15),10(14),11(13) -trien-1α,5α,6β,7αH-12,6-olide (8β)- hydroxydehydrozaluzanin), 8β,15-dihydroxy-2-oxo-guaia-1(10),3,11(13)-trien- 5α,6β,7αH-12,6-olide (lactucin), 3β8α,10α- trihydroxy-guaia-4(15),11(13)-dien-1α,5α,6β,7αH-12, 6-olide (10α-hydroxy-10,14-dihydro-desacylcynaropicrin) and 3β-D-glucopyranosyloxy-8β-(p-hydroxyphenylacetyloxy)-guaia-4(15), 10(14),11(13)-trien-1α,5α,6β,7αH-12,6-olide (8-epicrepioside) were identified. The structures were determined on the basis of spectral analyses, especially 1- and 2D NMR. Compound 1 exhibited significant cytotoxicity against human PC-3 tumor cells. ? 2005 Pharmaceutical Society of Japan. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-18744392004&doi=10.1248%2fcpb.53.15&partnerID=40&md5=07fce70733cbd47eb63258a9c2c8b63c https://scholars.lib.ntu.edu.tw/handle/123456789/564864 |
ISSN: | 92363 | DOI: | 10.1248/cpb.53.15 | SDG/Keyword: | 10alpha hydroxy 10,14 dihydrodesacylcynaropicrin; 8 epicrepioside; 8beta hydroxydehydrozaluzanin; guaianolide derivative; Ixeris chinensis extract; ixerochinolide; ixerochinoside; lactucin; sesquiterpene lactone derivative; unclassified drug; lactone; plant extract; sesquiterpene; article; Asteraceae; Chinese medicine; cytotoxicity; drug activity; drug identification; drug isolation; drug structure; herbal medicine; human; human cell; Ixeris chinensis; medicinal plant; nonhuman; nuclear magnetic resonance; phytochemistry; structure analysis; Asteraceae; chemistry; isolation and purification; plant; tumor cell line; Asteraceae; Cell Line, Tumor; Humans; Lactones; Plant Components, Aerial; Plant Extracts; Sesquiterpenes |
Appears in Collections: | 藥學系 |
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