https://scholars.lib.ntu.edu.tw/handle/123456789/568636
標題: | Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma | 作者: | Chou Y.-C. MING-WHEI YU Wu C.-F. Yang S.-Y. Lin C.-L. CHUN-JEN LIU Shin W.-L. PEI-JER CHEN Liaw Y.-F. Chen C.-J. |
公開日期: | 2008 | 卷: | 57 | 期: | 1 | 起(迄)頁: | 91-97 | 來源出版物: | Gut | 摘要: | Background and aims: To investigate the temporal relationship between sequence variation in the enhancer II (EnhII), basal core promoter (BCP), and precore regions of hepatitis B virus (HBV) and the risk of hepatocellular carcinoma (HCC), we conducted a nested case-control study within a cohort of 4841 male HBV carriers who were recruited during the period 1988-1992. Methods: The HBV DNA sequence was determined in baseline blood samples taken from 132 incident cases and 204 controls. Base exchanges during follow-up in 71 cases were compared with 81 controls with samples taken during a similar length of follow-up. Results: Nine single nucleotide polymorphisms in the EnhII/BCP regions (six of which were genotype C HBV related) were associated with subsequent risk of HCC. The strength of these associations decreased as the lag time between baseline measurement and diagnosis increased over 3 years. However, an increased disease risk in subjects with BCP double variants (mostly T1762/A1764) or genotype C HBV-related variants was evident 9 years or more before diagnosis. The BCP double variants (odds ratio, 1.92 (95% confidence interval, 1.14 to 3.25)) were statistically significantly associated with HCC risk even after adjusting for alanine aminotransferase levels, antibodies against HBV e antigen, HBV genotype, HBV viral load, and other sequence variants. Longitudinal analysis indicated that the increased HCC risks for at-risk sequence variants were attributable to the persistence of these variants. Conclusions: HCC risk is associated with sequence variation in the EnhII/BCP regions of HBV, and persistence of at-risk sequence variants is critical for HCC development. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-38349105023&doi=10.1136%2fgut.2006.114066&partnerID=40&md5=42c7fc4aa0a01696f8e11752d8be4f3a https://scholars.lib.ntu.edu.tw/handle/123456789/568636 |
ISSN: | 0017-5749 | DOI: | 10.1136/gut.2006.114066 | SDG/關鍵字: | adult; article; blood sampling; cancer diagnosis; cancer patient; case control study; comparative study; confidence interval; control group; controlled study; disease duration; DNA sequence; follow up; genotype; helper virus; hepatitis B; Hepatitis B virus; human; liver cell carcinoma; longitudinal study; major clinical study; male; priority journal; promoter region; risk factor; single nucleotide polymorphism; statistical significance; Adult; Carcinoma, Hepatocellular; Case-Control Studies; Cohort Studies; Enhancer Elements (Genetics); Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Promoter Regions (Genetics); Risk Factors |
顯示於: | 臨床醫學研究所 |
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