https://scholars.lib.ntu.edu.tw/handle/123456789/568846
Title: | Interspousal transmission of GB virus-C/Hepatitis G virus: A comparison with hepatitis C virus | Authors: | JIA-HORNG KAO CHUN-JEN LIU PEI-JER CHEN Chen W. Hsiang S.-C. Lai M.-Y. DING-SHINN CHEN |
Issue Date: | 1997 | Publisher: | John Wiley and Sons Inc. | Journal Volume: | 53 | Journal Issue: | 4 | Start page/Pages: | 348-353 | Source: | Journal of Medical Virology | Abstract: | Although infection with GB virus-C/hepatitis G virus (GBV-C/HGV) by blood transfusion is well documented, little is known about the other routes of transmission. The prevalence of GBV-C/HGV infection in spouses of index patients and the related risk factors were studied. Hepatitis C virus (HCV) and GBV-C/HGV infections were studied in spouses of 100 patients with hepatitis C, of whom 12 were found to be also positive for GBV-C/HGV RNA. For couples both with GBV-C/HGV viremia, nucleotide sequences of the divergent envelope region were analyzed by phylogenetic tree constructions. For HCV infection, anti-HCV was found in 14 (14%) of the 100 spouses. Five spouses (42%) of the 12 patients with dual infection of GBV-C/HGV and HCV had evidence of GBV-C/HGV infection, three had viral RNA, and two had antibodies to a recombinant HGV envelope protein E2. Nucleotide sequence comparison and phylogenetic tree analysis of the genome in the GBV-C/HGV infected couple revealed the isolates to be closely related. These results suggest that spouses of patients with GBV-C/HGV infection are at a higher risk of acquiring GBV-C/HGV as compared with HCV, and they should be educated to avoid GBV-C/HGV infection from their spouses, in case GBV-C/HGV is shown to be pathogenic. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984537091&doi=10.1002%2f%28SICI%291096-9071%28199712%2953%3a4%3c348%3a%3aAID-JMV6%3e3.0.CO%3b2-7&partnerID=40&md5=cdb8f2bd29f4e6e68bb8b7a43a6bd446 https://scholars.lib.ntu.edu.tw/handle/123456789/568846 |
ISSN: | 0146-6615 | DOI: | 10.1002/(SICI)1096-9071(199712)53:4<348 | SDG/Keyword: | adult; aged; article; blood transfusion; female; Hepatitis C virus; Hepatitis G virus; human; major clinical study; male; phylogeny; risk factor; spouse; virus gene; virus isolation; virus transmission; GB virus C/Hepatitis G virus; Hepatitis C virus |
Appears in Collections: | 臨床醫學研究所 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.