https://scholars.lib.ntu.edu.tw/handle/123456789/568904
標題: | A viral mechanism in acute exacerbations of chronic type B hepatitis: Hepatitis B virus reinfection and subsequent reactivation of two viral strains | 作者: | PEI-JER CHEN Chen M.L. Chen D.S. |
關鍵字: | Chronic type B hepatitis; Hepatitis B virus reinfection; Mixed viral strains in acute exacerbations | 公開日期: | 1993 | 出版社: | Kluwer Academic Publishers | 卷: | 1 | 期: | 1 | 起(迄)頁: | 7-12 | 來源出版物: | Journal of Biomedical Science | 摘要: | Chronic hepatitis B virus (HBV) infections are frequently associated with exacerbations of hepatitis of which the majority are due to reactivation of viral activity. Variation in a viral genome during persistent infection has been shown to be a possible cause for reactivation. In this study, we have found another possible mechanism. HBV in a patient with repeated exacerbations was isolated at six different times during follow-up and was characterized by polymerase chain reaction and DNA sequencing. The first episode of exacerbation was accompanied with increased replication of an HBV strain. The second episode, however, was associated with the sudden appearance of an HBV strain that displayed enough sequence variations to warrant the designation as a separate strain. The results suggested a reinfection event by another independent HBV. Subsequent exacerbations were then related to coactivation of both viral stains. These observations provide significant information toward understanding the acute exacerbations of chronic type B hepatitis. ? 1994 National Science Council. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984538400&doi=10.1007%2fBF02258334&partnerID=40&md5=77818e892143b8d707f15e3d0c009c59 https://scholars.lib.ntu.edu.tw/handle/123456789/568904 |
ISSN: | 1021-7770 | DOI: | 10.1007/BF02258334 |
顯示於: | 臨床醫學研究所 |
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