https://scholars.lib.ntu.edu.tw/handle/123456789/569198
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kuo R.-C. | en_US |
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | YEN-PING KUO | en_US |
dc.date.accessioned | 2021-07-05T05:42:15Z | - |
dc.date.available | 2021-07-05T05:42:15Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644540519&doi=10.1016%2fS0929-6646%2809%2960310-7&partnerID=40&md5=7604731c6f93d5972a6261e6d5689a1b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/569198 | - |
dc.description.abstract | Background: Overexpression or activation of c-Jun has been implicated in the pathogenesis of several types of cancer. Treatment of oral cells with areca nut extract in culture can increase c-Jun proto-oncogene mRNA levels. The purpose of this study was to investigate the possible role of c-Jun activation in the pathogenesis and prognosis of areca quid chewing-related oral cancer in Taiwan. Methods: We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections. Results: Positive pc-Jun staining was observed in 42 of 70 (60%) cases of oral SCC. No significant correlation was found between pc-Jun expression and patients' age, gender, oral habit, cancer location, clinical stage, tumor size and lymph node status. Kaplan-Meier curves showed that oral SCC patients with positive pc-Jun staining or positive lymph node metastasis had significantly shorter overall survival (p < 0.018 and 0.001, respectively, by log-rank test). Conclusion: These results indicate that c-Jun activation may play an important role in the carcinogenesis of oral SCC. Positive pc-Jun staining may serve as an adjuvant marker of worse prognosis in patients with oral SCC in Taiwan. ?2006 Elsevier & Formosan Medical Association. | - |
dc.publisher | Scientific Communications International Ltd | - |
dc.relation.ispartof | Journal of the Formosan Medical Association | - |
dc.subject | c-Jun activation; Oral cancer; Prognosis | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | paraffin; protein c jun; age; article; betel nut; cancer patient; cancer staging; cancer survival; carcinogenesis; controlled study; correlation analysis; disease association; female; gene activation; gene overexpression; human; human tissue; immunohistochemistry; Kaplan Meier method; log rank test; lymph node metastasis; major clinical study; male; mouth carcinoma; prognosis; sex difference; squamous cell carcinoma; Taiwan; tumor localization; tumor volume | - |
dc.title | Prognostic role of c-Jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0929-6646(09)60310-7 | - |
dc.identifier.pmid | 16520839 | - |
dc.identifier.scopus | 2-s2.0-33644540519 | - |
dc.relation.pages | 229-234 | - |
dc.relation.journalvolume | 105 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.orcid | 0000-0001-8321-2575 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 牙醫學系 |
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