https://scholars.lib.ntu.edu.tw/handle/123456789/569198
Title: | Prognostic role of c-Jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan | Authors: | Kuo R.-C. Lin C.-Y. YEN-PING KUO |
Keywords: | c-Jun activation; Oral cancer; Prognosis | Issue Date: | 2006 | Publisher: | Scientific Communications International Ltd | Journal Volume: | 105 | Journal Issue: | 3 | Start page/Pages: | 229-234 | Source: | Journal of the Formosan Medical Association | Abstract: | Background: Overexpression or activation of c-Jun has been implicated in the pathogenesis of several types of cancer. Treatment of oral cells with areca nut extract in culture can increase c-Jun proto-oncogene mRNA levels. The purpose of this study was to investigate the possible role of c-Jun activation in the pathogenesis and prognosis of areca quid chewing-related oral cancer in Taiwan. Methods: We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections. Results: Positive pc-Jun staining was observed in 42 of 70 (60%) cases of oral SCC. No significant correlation was found between pc-Jun expression and patients' age, gender, oral habit, cancer location, clinical stage, tumor size and lymph node status. Kaplan-Meier curves showed that oral SCC patients with positive pc-Jun staining or positive lymph node metastasis had significantly shorter overall survival (p < 0.018 and 0.001, respectively, by log-rank test). Conclusion: These results indicate that c-Jun activation may play an important role in the carcinogenesis of oral SCC. Positive pc-Jun staining may serve as an adjuvant marker of worse prognosis in patients with oral SCC in Taiwan. ?2006 Elsevier & Formosan Medical Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33644540519&doi=10.1016%2fS0929-6646%2809%2960310-7&partnerID=40&md5=7604731c6f93d5972a6261e6d5689a1b https://scholars.lib.ntu.edu.tw/handle/123456789/569198 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60310-7 | SDG/Keyword: | paraffin; protein c jun; age; article; betel nut; cancer patient; cancer staging; cancer survival; carcinogenesis; controlled study; correlation analysis; disease association; female; gene activation; gene overexpression; human; human tissue; immunohistochemistry; Kaplan Meier method; log rank test; lymph node metastasis; major clinical study; male; mouth carcinoma; prognosis; sex difference; squamous cell carcinoma; Taiwan; tumor localization; tumor volume |
Appears in Collections: | 牙醫學系 |
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