https://scholars.lib.ntu.edu.tw/handle/123456789/570387
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chang C.-H. | en_US |
dc.contributor.author | Wu Y.-C. | en_US |
dc.contributor.author | Wu Y.-H. | en_US |
dc.contributor.author | Sun A. | en_US |
dc.contributor.author | SHIH-JUNG CHENG | en_US |
dc.contributor.author | HSIN-MING CHEN | en_US |
dc.date.accessioned | 2021-07-07T03:41:12Z | - |
dc.date.available | 2021-07-07T03:41:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025838672&doi=10.1016%2fj.jfma.2017.04.002&partnerID=40&md5=20ef704dc06a169f55b58fc05db81a94 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/570387 | - |
dc.description.abstract | Background/Purpose Langerhans cells (LCs) are antigen-presenting cells. This study assessed the LC counts in odontogenic keratocysts (OKCs). Methods The LC numbers in the lining epithelia and subepithelial connective tissues were counted at 60 OKC sites without inflammation, 39 OKC sites with mild/moderate inflammation, and 13 OKC sites with severe inflammation from 60 OKC specimens immunostained with anti-S100 antibodies. Results The mean LC counts in the lining epithelia and subepithelial connective tissues increased significantly from no inflammation (0.5 ± 0.4 and 0.7 ± 0.6 cell/high-power field or HPF, respectively) through mild/moderate inflammation (5.9 ± 2.7 and 5.0 ± 3.5 cells/HPF, respectively) to severe inflammation OKC sites (14.7 ± 5.3 and 13.3 ± 6.8 cells/HPF, respectively; all P-values < 0.001). OKC sites with inflammation had thicker lining epithelia than those without inflammation. Moreover, the mean LC counts in the lining epithelia and subepithelial connective tissues of OKCs were significantly higher in the thicker lining epithelium (>100 μm) group (7.7 ± 5.6 and 6.5 ± 5.8 cells/HPF, respectively) than in the thinner lining epithelium (≦ 100 μm) group (1.0 ± 2.0 and 1.4 ± 2.6 cells/HPF, respectively; both P-values < 0.001). Conclusion A significant association of inflammation grade with the number of LCs in OKCs is found. The paucity of finding LCs in the lining epithelia of OKCs without inflammation indicates the loss of immunosurveillance ability against the OKC lining epithelial cells; this can explain why OKCs have aggressive clinical behavior, a great growth potential, and a high recurrence rate. ? 2017 | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.ispartof | Journal of the Formosan Medical Association | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; Article; cell count; connective tissue; controlled study; correlational study; disease association; disease severity; enucleation; female; human; immunohistochemistry; immunosurveillance; inflammation; Langerhans cell; major clinical study; male; odontogenic keratocyst; recurrence risk; squamous epithelium cell; adolescent; aged; child; complication; cytology; epithelium; immunological monitoring; inflammation; Langerhans cell; metabolism; middle aged; odontogenic cyst; odontogenic tumor; pathology; tumor recurrence; young adult; protein S 100; Adolescent; Adult; Aged; Child; Epithelium; Female; Humans; Inflammation; Langerhans Cells; Male; Middle Aged; Monitoring, Immunologic; Neoplasm Recurrence, Local; Odontogenic Cysts; Odontogenic Tumors; S100 Proteins; Young Adult | - |
dc.title | Significant association of inflammation grade with the number of Langerhans cells in odontogenic keratocysts | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jfma.2017.04.002 | - |
dc.identifier.pmid | 28755796 | - |
dc.identifier.scopus | 2-s2.0-85025838672 | - |
dc.relation.pages | 798-805 | - |
dc.relation.journalvolume | 116 | - |
dc.relation.journalissue | 10 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.orcid | 0000-0003-4674-4892 | - |
crisitem.author.orcid | 0000-0002-6118-1234 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 牙醫學系 |
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