https://scholars.lib.ntu.edu.tw/handle/123456789/570387
Title: | Significant association of inflammation grade with the number of Langerhans cells in odontogenic keratocysts | Authors: | Chang C.-H. Wu Y.-C. Wu Y.-H. Sun A. SHIH-JUNG CHENG HSIN-MING CHEN |
Issue Date: | 2017 | Publisher: | Elsevier B.V. | Journal Volume: | 116 | Journal Issue: | 10 | Start page/Pages: | 798-805 | Source: | Journal of the Formosan Medical Association | Abstract: | Background/Purpose Langerhans cells (LCs) are antigen-presenting cells. This study assessed the LC counts in odontogenic keratocysts (OKCs). Methods The LC numbers in the lining epithelia and subepithelial connective tissues were counted at 60 OKC sites without inflammation, 39 OKC sites with mild/moderate inflammation, and 13 OKC sites with severe inflammation from 60 OKC specimens immunostained with anti-S100 antibodies. Results The mean LC counts in the lining epithelia and subepithelial connective tissues increased significantly from no inflammation (0.5 ± 0.4 and 0.7 ± 0.6 cell/high-power field or HPF, respectively) through mild/moderate inflammation (5.9 ± 2.7 and 5.0 ± 3.5 cells/HPF, respectively) to severe inflammation OKC sites (14.7 ± 5.3 and 13.3 ± 6.8 cells/HPF, respectively; all P-values < 0.001). OKC sites with inflammation had thicker lining epithelia than those without inflammation. Moreover, the mean LC counts in the lining epithelia and subepithelial connective tissues of OKCs were significantly higher in the thicker lining epithelium (>100 μm) group (7.7 ± 5.6 and 6.5 ± 5.8 cells/HPF, respectively) than in the thinner lining epithelium (≦ 100 μm) group (1.0 ± 2.0 and 1.4 ± 2.6 cells/HPF, respectively; both P-values < 0.001). Conclusion A significant association of inflammation grade with the number of LCs in OKCs is found. The paucity of finding LCs in the lining epithelia of OKCs without inflammation indicates the loss of immunosurveillance ability against the OKC lining epithelial cells; this can explain why OKCs have aggressive clinical behavior, a great growth potential, and a high recurrence rate. ? 2017 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025838672&doi=10.1016%2fj.jfma.2017.04.002&partnerID=40&md5=20ef704dc06a169f55b58fc05db81a94 https://scholars.lib.ntu.edu.tw/handle/123456789/570387 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2017.04.002 | SDG/Keyword: | adult; Article; cell count; connective tissue; controlled study; correlational study; disease association; disease severity; enucleation; female; human; immunohistochemistry; immunosurveillance; inflammation; Langerhans cell; major clinical study; male; odontogenic keratocyst; recurrence risk; squamous epithelium cell; adolescent; aged; child; complication; cytology; epithelium; immunological monitoring; inflammation; Langerhans cell; metabolism; middle aged; odontogenic cyst; odontogenic tumor; pathology; tumor recurrence; young adult; protein S 100; Adolescent; Adult; Aged; Child; Epithelium; Female; Humans; Inflammation; Langerhans Cells; Male; Middle Aged; Monitoring, Immunologic; Neoplasm Recurrence, Local; Odontogenic Cysts; Odontogenic Tumors; S100 Proteins; Young Adult |
Appears in Collections: | 牙醫學系 |
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