https://scholars.lib.ntu.edu.tw/handle/123456789/571484
標題: | Transformation of ginsenosides Rg1 and Rb1, and crude Sanchi saponins by human intestinal microflora | 作者: | Lin M.-C. Wang K.-C. SHOEI-SHENG LEE |
關鍵字: | 20(22)Z-Ginsenoside Rh4; 20R-ginsenoside Rh1; Human microflora; Microbial transformation; Sanchi saponins | 公開日期: | 2001 | 卷: | 48 | 期: | 1 | 起(迄)頁: | 113-120 | 來源出版物: | Journal of the Chinese Chemical Society | 摘要: | Fractions major in ginsenosides Rg1 and Rb1 from Sanchi saponins were transformed by human fecal flora. This study yielded the corresponding aglycone, protopanaxatriol, in 49.4% from Rg1, protopanaxadiol 20-O-glucoside in 54.8% from Rb1, and dihydroprotopanaxadiol 20-O-glucoside in 87.6% from dihydro Rb1, by incubation with healthy feces for 70 h in subgram level. Nevertheless large-scale incubation of crude Sanchi saponins revealed the complete biotransformation of Rb1 and the almost unchanged Rg1. A small amount of Rg1 was found to be converted into 20R-ginsenoside Rh1 and its dehydration product, 20(22)Z-ginsenoside Rh4. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0242723003&doi=10.1002%2fjccs.200100021&partnerID=40&md5=d695ce37399db2a63ef267fff71b8d3b https://scholars.lib.ntu.edu.tw/handle/123456789/571484 |
ISSN: | 94536 | DOI: | 10.1002/jccs.200100021 |
顯示於: | 藥學系 |
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