https://scholars.lib.ntu.edu.tw/handle/123456789/572027
標題: | Factors associated with low bone mass in the hemodialysis patients-a cross-sectional correlation study | 作者: | Huang G.-S. TZONG-SHINN CHU Lou M.-F. Hwang S.-L. RONG-SEN YANG |
公開日期: | 2009 | 卷: | 10 | 期: | 1 | 來源出版物: | BMC Musculoskeletal Disorders | 摘要: | Background. Low bone mass is common in end-stage renal disease patients, especially those undergoing hemodialysis. It can lead to serious bone health problems such as fragility fractures. The purpose of this study is to investigate the risk factors of low bone mass in the hemodialysis patients. Methods. Sixty-three subjects on hemodialysis for at least 6 months were recruited from a single center for this cross-sectional study. We collected data by questionnaire survey and medical records review. All subjects underwent a bone mineral density (BMD) assay with dual-energy x-ray absorptiometry at the lumbar spine and right hip. Data were statistically analyzed by means of descriptive analysis, independent t test and one way analysis of variance for continuous variables, Pearson product-moment correlation to explore the correlated factors of BMD, and stepwise multiple linear regression to identify the predictors of low bone mass. Results. Using WHO criteria as a cutoff point, fifty-one subjects (81%) had a T-score lower than -1, of them 8 subjects (13%) had osteoporosis with the femoral neck most commonly affected. Regarding risk factors, age, serum alkaline phosphatase (ALP) level, and intact parathyroid hormone (iPTH) level had significant negative correlations with the femoral neck and lumbar spine BMD. On the other hand, serum albumin level, effective exercise time, and body weight (BW) had significant positive correlations with the femoral neck and lumbar spine BMD. Age, effective exercise time, and serum albumin level significantly predicted the femoral neck BMD (R2× 0.25), whereas BW and the ALP level significantly predicted the lumbar spine BMD (R2× 0.20). Conclusion. This study showed that advanced age, low BW, low serum albumin level, and high ALP and iPTH levels were associated with a low bone mass in the hemodialysis patients. We suggest that regular monitoring of the femoral neck BMD, maintaining an adequate serum albumin level and BW, and undertaking an exercise program are important to improve bone health in the patients undergoing hemodialysis. ? 2009 Huang et al; licensee BioMed Central Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67651174720&doi=10.1186%2f1471-2474-10-60&partnerID=40&md5=f3a6922eeeedb21ee9c9e7c9e8793e4e https://scholars.lib.ntu.edu.tw/handle/123456789/572027 |
ISSN: | 1471-2474 | DOI: | 10.1186/1471-2474-10-60 | SDG/關鍵字: | albumin; alkaline phosphatase; calcium; parathyroid hormone; phosphate; alkaline phosphatase; parathyroid hormone; serum albumin; adult; aged; albumin blood level; alkaline phosphatase blood level; article; blood sampling; body weight; bone density; bone mass; calcium blood level; correlational study; cross-sectional study; disease association; dual energy X ray absorptiometry; exercise; female; femur neck; hemodialysis; hip; human; lumbar spine; major clinical study; male; medical record review; osteopenia; osteoporosis; parathyroid hormone blood level; phosphate blood level; questionnaire; retrospective study; risk factor; structured interview; age; blood; chronic kidney failure; fitness; kinesiotherapy; lumbar vertebra; middle aged; osteoporosis; pathology; pathophysiology; photon absorptiometry; physiology; radiography; renal replacement therapy; standard; Absorptiometry, Photon; Adult; Age Factors; Aged; Alkaline Phosphatase; Body Weight; Bone Density; Cross-Sectional Studies; Exercise Therapy; Female; Femur Neck; Humans; Kidney Failure, Chronic; Lumbar Vertebrae; Male; Middle Aged; Osteoporosis; Parathyroid Hormone; Physical Fitness; Renal Dialysis; Risk Factors; Serum Albumin |
顯示於: | 醫學教育暨生醫倫理學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。