Factors associated with low bone mass in the hemodialysis patients-a cross-sectional correlation study
Journal
BMC Musculoskeletal Disorders
Journal Volume
10
Journal Volume
10
Journal Issue
1
Journal Issue
1
Start Page
60
ISSN
1471-2474
Date Issued
2009
Author(s)
Abstract
Background. Low bone mass is common in end-stage renal disease patients, especially those undergoing hemodialysis. It can lead to serious bone health problems such as fragility fractures. The purpose of this study is to investigate the risk factors of low bone mass in the hemodialysis patients. Methods. Sixty-three subjects on hemodialysis for at least 6 months were recruited from a single center for this cross-sectional study. We collected data by questionnaire survey and medical records review. All subjects underwent a bone mineral density (BMD) assay with dual-energy x-ray absorptiometry at the lumbar spine and right hip. Data were statistically analyzed by means of descriptive analysis, independent t test and one way analysis of variance for continuous variables, Pearson product-moment correlation to explore the correlated factors of BMD, and stepwise multiple linear regression to identify the predictors of low bone mass. Results. Using WHO criteria as a cutoff point, fifty-one subjects (81%) had a T-score lower than -1, of them 8 subjects (13%) had osteoporosis with the femoral neck most commonly affected. Regarding risk factors, age, serum alkaline phosphatase (ALP) level, and intact parathyroid hormone (iPTH) level had significant negative correlations with the femoral neck and lumbar spine BMD. On the other hand, serum albumin level, effective exercise time, and body weight (BW) had significant positive correlations with the femoral neck and lumbar spine BMD. Age, effective exercise time, and serum albumin level significantly predicted the femoral neck BMD (R2× 0.25), whereas BW and the ALP level significantly predicted the lumbar spine BMD (R2× 0.20). Conclusion. This study showed that advanced age, low BW, low serum albumin level, and high ALP and iPTH levels were associated with a low bone mass in the hemodialysis patients. We suggest that regular monitoring of the femoral neck BMD, maintaining an adequate serum albumin level and BW, and undertaking an exercise program are important to improve bone health in the patients undergoing hemodialysis. ? 2009 Huang et al; licensee BioMed Central Ltd.
SDGs
Other Subjects
albumin; alkaline phosphatase; calcium; parathyroid hormone; phosphate; alkaline phosphatase; parathyroid hormone; serum albumin; adult; aged; albumin blood level; alkaline phosphatase blood level; article; blood sampling; body weight; bone density; bone mass; calcium blood level; correlational study; cross-sectional study; disease association; dual energy X ray absorptiometry; exercise; female; femur neck; hemodialysis; hip; human; lumbar spine; major clinical study; male; medical record review; osteopenia; osteoporosis; parathyroid hormone blood level; phosphate blood level; questionnaire; retrospective study; risk factor; structured interview; age; blood; chronic kidney failure; fitness; kinesiotherapy; lumbar vertebra; middle aged; osteoporosis; pathology; pathophysiology; photon absorptiometry; physiology; radiography; renal replacement therapy; standard; Absorptiometry, Photon; Adult; Age Factors; Aged; Alkaline Phosphatase; Body Weight; Bone Density; Cross-Sectional Studies; Exercise Therapy; Female; Femur Neck; Humans; Kidney Failure, Chronic; Lumbar Vertebrae; Male; Middle Aged; Osteoporosis; Parathyroid Hormone; Physical Fitness; Renal Dialysis; Risk Factors; Serum Albumin
Type
journal article