https://scholars.lib.ntu.edu.tw/handle/123456789/580816
標題: | Design and Implementation of a Dual-Transmit/ Receive-Mode Therapeutic Ultrasound Phased Array System for Brain Therapy | 作者: | Liu H.-L Jan C.-K Tsai C.-H Huang S.-M Li M.-L Qiu W Zheng H. HAO-LI LIU |
關鍵字: | Blood; Real time systems; Blood-brain barrier; Brain therapy; Coherent beams; Dual transmit/receive mode; Ultrasound phased arrays; Ultrasonics | 公開日期: | 2018 | 卷: | 2018-October | 來源出版物: | IEEE International Ultrasonics Symposium, IUS | 摘要: | Focused ultrasound phased array systems have attracted increased attention for brain therapy applications. However, such systems currently lack a direct and real-time method to intraoperatively monitor ultrasound pressure distribution for securing treatment. This study proposes a dual-mode 256-channel ultrasound phased array system design to support transmit/receive operations for concurrent ultrasound exposure and backscattered focal-beam reconstruction through a spherically focused ultrasound array. A total 256-channel ultrasound transmission system was used to transmit focused ultrasonic energy, with an extended implementation of multiple-channel receiving function (up to 64 channels) using the same 256-channel ultrasound array. Our results showed that PSF and focal beam can be successfully reconstructed and visualized in free-field conditions, and can also be transcranially reconstructed following skull-induced aberration correction. In-vivo experiments were conducted to demonstrate its capability to pre-operatively and semi-quantitatively map a focal beam to guide blood-brain barrier (BBB)-opening. The proposed system may have potential for real-time guidance of ultrasound brain intervention, and may facilitate the design of a dual-mode ultrasound phased array for brain therapeutic applications. ? 2018 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060639873&doi=10.1109%2fULTSYM.2018.8579682&partnerID=40&md5=5f308c161118f3f094651d44e32e0a43 https://scholars.lib.ntu.edu.tw/handle/123456789/580816 |
ISSN: | 19485719 | DOI: | 10.1109/ULTSYM.2018.8579682 |
顯示於: | 電機工程學系 |
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