https://scholars.lib.ntu.edu.tw/handle/123456789/580817
標題: | Design and Implementation of a Transmit/Receive Ultrasound Phased Array for Brain Applications | 作者: | Liu H.-L Tsai C.-H Jan C.-K Chang H.-Y Huang S.-M Li M.-L Qiu W Zheng H. HAO-LI LIU |
關鍵字: | Acoustics; Antenna phased arrays; Backscattering; Blood; Coherent scattering; Image reconstruction; Optical transfer function; Real time systems; Ultrasonic imaging; Acoustic beams; Blood-brain barrier; Brain therapy; Coherent beams; Dual transmit/receive mode; Radio frequencies; Ultrasound phased arrays; Field programmable gate arrays (FPGA); algorithm; animal; blood brain barrier; brain; devices; diagnostic imaging; echography; equipment design; human; image processing; imaging phantom; male; microbubble; nuclear magnetic resonance imaging; procedures; rat; skull; ultrasound therapy; Algorithms; Animals; Blood-Brain Barrier; Brain; Equipment Design; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Microbubbles; Phantoms, Imaging; Rats; Skull; Ultrasonic Therapy; Ultrasonography | 公開日期: | 2018 | 卷: | 65 | 期: | 10 | 起(迄)頁: | 1756-1767 | 來源出版物: | IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control | 摘要: | Focused ultrasound phased array systems have attracted increased attention for brain therapy applications. However, such systems currently lack a direct and real-time method to intraoperatively monitor ultrasound pressure distribution for securing treatment. This study proposes a dual-mode ultrasound phased array system design to support transmit/receive operations for concurrent ultrasound exposure and backscattered focal beam reconstruction through a spherically focused ultrasound array. A 256-channel ultrasound transmission system was used to transmit focused ultrasonic energy (full 256 channels), with an extended implementation of multiple-channel receiving function (up to 64 channels) using the same 256-channel ultrasound array. A coherent backscatter-received beam formation algorithm was implemented to map the point spread function (PSF) and focal beam distribution under a free-field/transcranial environment setup, with the backscattering generated from a strong scatterer (a point reflector or a microbubble-perfused tube) or a weakly scattered tissue-mimicking graphite phantom. Our results showed that PSF and focal beam can be successfully reconstructed and visualized in free-field conditions and can also be transcranially reconstructed following skull-induced aberration correction. In vivo experiments were conducted to demonstrate its capability to preoperatively and semiquantitatively map a focal beam to guide blood-brain barrier opening. The proposed system may have potential for real-time guidance of ultrasound brain intervention, and may facilitate the design of a dual-mode ultrasound phased array for brain therapeutic applications. ? 2018 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049979291&doi=10.1109%2fTUFFC.2018.2855181&partnerID=40&md5=3c9ca2ccbaa44b8c121cccbd3b773b14 https://scholars.lib.ntu.edu.tw/handle/123456789/580817 |
ISSN: | 08853010 | DOI: | 10.1109/TUFFC.2018.2855181 |
顯示於: | 電機工程學系 |
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