https://scholars.lib.ntu.edu.tw/handle/123456789/582970
標題: | Mirin: Identifying microRNA regulatory modules in protein-protein interaction networks | 作者: | Yang K.-C. CHIA-LANG HSU Lin C.-C. Juan H.-F. Huang H.-C. |
公開日期: | 2014 | 出版社: | Oxford University Press | 卷: | 30 | 期: | 17 | 起(迄)頁: | 2527-2528 | 來源出版物: | Bioinformatics | 摘要: | Summary: Exploring microRNA (miRNA) regulations and protein- protein interactions could reveal the molecular mechanisms responsible for complex biological processes. Mirin is a web-based application suitable for identifying functional modules from protein- protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. The analysis involves combining miRNA regulations, protein-protein interactions between target genes, as well as mRNA and miRNA expression profiles provided by users. Mirin has successfully uncovered oncomirs and their regulatory networks in various cancers, such as gastric and breast cancer. ? The Author 2014. Published by Oxford University Press. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84907029461&doi=10.1093%2fbioinformatics%2fbtu306&partnerID=40&md5=386c5e4c55fb3746963c595b0a19205b https://scholars.lib.ntu.edu.tw/handle/123456789/582970 |
ISSN: | 1367-4803 | DOI: | 10.1093/bioinformatics/btu306 | SDG/關鍵字: | messenger RNA; microRNA; breast tumor; computer program; female; gene expression regulation; gene regulatory network; genetics; human; metabolism; protein analysis; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; MicroRNAs; Protein Interaction Mapping; RNA, Messenger; Software |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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