Mirin: Identifying microRNA regulatory modules in protein-protein interaction networks
Journal
Bioinformatics
Journal Volume
30
Journal Issue
17
Pages
2527-2528
Date Issued
2014
Author(s)
Abstract
Summary: Exploring microRNA (miRNA) regulations and protein- protein interactions could reveal the molecular mechanisms responsible for complex biological processes. Mirin is a web-based application suitable for identifying functional modules from protein- protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. The analysis involves combining miRNA regulations, protein-protein interactions between target genes, as well as mRNA and miRNA expression profiles provided by users. Mirin has successfully uncovered oncomirs and their regulatory networks in various cancers, such as gastric and breast cancer. ? The Author 2014. Published by Oxford University Press. All rights reserved.
SDGs
Other Subjects
messenger RNA; microRNA; breast tumor; computer program; female; gene expression regulation; gene regulatory network; genetics; human; metabolism; protein analysis; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; MicroRNAs; Protein Interaction Mapping; RNA, Messenger; Software
Publisher
Oxford University Press
Type
journal article