https://scholars.lib.ntu.edu.tw/handle/123456789/586867
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tsai H.-H. | en_US |
dc.contributor.author | LI-KAI TSAI | en_US |
dc.contributor.author | Lo Y.-L. | en_US |
dc.contributor.author | CHIN-HSIEN LIN | en_US |
dc.date.accessioned | 2021-11-16T02:43:55Z | - |
dc.date.available | 2021-11-16T02:43:55Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 20452322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103549667&doi=10.1038%2fs41598-021-86617-0&partnerID=40&md5=3c007b40efc0be4d09c3a41c284e85e3 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/586867 | - |
dc.description.abstract | Cerebral microbleeds (MBs) have been found in patients with cognitive decline. We aimed to examine whether MBs are associated with motor or cognitive decline in patients with Parkinson’s disease (PD). We enrolled 135 PD patients and 34 healthy controls. All participants underwent brain MRI and plasma biomarker assays, including tau, Aβ42, Aβ40, and α-synuclein. PD with dementia (PDD) was operationally defined as Mini-Mental State Examination (MMSE) score < 26 and advanced motor stage was defined as Hoehn-Yahr stage ? 3 during “on” status. The association between MBs and disease severity was examined using multivariate logistic regression models. More lobar MBs were observed in PD patients than controls (20.7% vs. 3.3%, p = 0.031). PDD patients had more lobar MBs (33.3% vs. 15.6%, p = 0.034), more white matter hyperintensity (p = 0.021) and reduced hippocampal volume (p = 0.001) than PD with normal cognition. The presence of lobar MB (odds ratio = 2.83 [95% confidence interval 1.04–7.70], p = 0.042) and severe white matter hyperintensity (3.29 [1.21–8.96], p = 0.020) was independently associated with PDD after adjusting for vascular risk factors and other confounders. Furthermore, plasma Aβ40 levels were associated the MMSE score (p = 0.004) after adjusting for age and sex. Our findings demonstrated that lobar MBs, reduced hippocampal volume, and elevated plasma Aβ40 levels are associated with PDD. ? 2021, The Author(s). | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amyloid beta protein; amyloid beta protein[1-40]; biological marker; peptide fragment; aged; blood; brain hemorrhage; case control study; cognitive defect; complication; diagnostic imaging; female; human; male; middle aged; nuclear magnetic resonance imaging; Parkinson disease; severity of illness index; Aged; Amyloid beta-Peptides; Biomarkers; Case-Control Studies; Cerebral Hemorrhage; Cognition Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Peptide Fragments; Severity of Illness Index | - |
dc.title | Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-021-86617-0 | - |
dc.identifier.pmid | 33782518 | - |
dc.identifier.scopus | 2-s2.0-85103549667 | - |
dc.relation.pages | 7115 | - |
dc.relation.journalvolume | 11 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.orcid | 0000-0001-8420-6951 | - |
crisitem.author.orcid | 0000-0001-8566-7573 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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