https://scholars.lib.ntu.edu.tw/handle/123456789/586867
標題: | Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease | 作者: | Tsai H.-H. LI-KAI TSAI Lo Y.-L. CHIN-HSIEN LIN |
公開日期: | 2021 | 卷: | 11 | 期: | 1 | 起(迄)頁: | 7115 | 來源出版物: | Scientific Reports | 摘要: | Cerebral microbleeds (MBs) have been found in patients with cognitive decline. We aimed to examine whether MBs are associated with motor or cognitive decline in patients with Parkinson’s disease (PD). We enrolled 135 PD patients and 34 healthy controls. All participants underwent brain MRI and plasma biomarker assays, including tau, Aβ42, Aβ40, and α-synuclein. PD with dementia (PDD) was operationally defined as Mini-Mental State Examination (MMSE) score < 26 and advanced motor stage was defined as Hoehn-Yahr stage ? 3 during “on” status. The association between MBs and disease severity was examined using multivariate logistic regression models. More lobar MBs were observed in PD patients than controls (20.7% vs. 3.3%, p = 0.031). PDD patients had more lobar MBs (33.3% vs. 15.6%, p = 0.034), more white matter hyperintensity (p = 0.021) and reduced hippocampal volume (p = 0.001) than PD with normal cognition. The presence of lobar MB (odds ratio = 2.83 [95% confidence interval 1.04–7.70], p = 0.042) and severe white matter hyperintensity (3.29 [1.21–8.96], p = 0.020) was independently associated with PDD after adjusting for vascular risk factors and other confounders. Furthermore, plasma Aβ40 levels were associated the MMSE score (p = 0.004) after adjusting for age and sex. Our findings demonstrated that lobar MBs, reduced hippocampal volume, and elevated plasma Aβ40 levels are associated with PDD. ? 2021, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103549667&doi=10.1038%2fs41598-021-86617-0&partnerID=40&md5=3c007b40efc0be4d09c3a41c284e85e3 https://scholars.lib.ntu.edu.tw/handle/123456789/586867 |
ISSN: | 20452322 | DOI: | 10.1038/s41598-021-86617-0 | SDG/關鍵字: | amyloid beta protein; amyloid beta protein[1-40]; biological marker; peptide fragment; aged; blood; brain hemorrhage; case control study; cognitive defect; complication; diagnostic imaging; female; human; male; middle aged; nuclear magnetic resonance imaging; Parkinson disease; severity of illness index; Aged; Amyloid beta-Peptides; Biomarkers; Case-Control Studies; Cerebral Hemorrhage; Cognition Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Peptide Fragments; Severity of Illness Index |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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