https://scholars.lib.ntu.edu.tw/handle/123456789/588829
Title: | Spirochetemia due to Treponema pallidum using polymerase-chain-reaction assays in patients with early syphilis: Prevalence, associated factors and treatment response | Authors: | Wu B.-R. Tsai M.-S. Yang C.-J. HSIN-YUN SUN Liu W.-C. Yang S.-P. Wu P.-Y. Su Y.-C. SUI-YUAN CHANG CHIEN-CHING HUNG |
Issue Date: | 2014 | Publisher: | Blackwell Publishing Ltd | Journal Volume: | 20 | Journal Issue: | 8 | Start page/Pages: | O524-O527 | Source: | Clinical Microbiology and Infection | Abstract: | Between 2009 and 2013, polymerase-chain-reaction assay was used to detect Treponema pallidum in the blood samples collected from 296 patients with early syphilis (241 being HIV infected) and 102 patients (34.5%) had spirochetemia. The presence of spirochetemia was associated with lower CD4 counts (per 10-cell/mm3 decrease, adjusted odds ratio (AOR), 1.020; 95% CI, 1.006-1.036) and secondary syphilis (AOR, 4.967; 95% CI, 2.016-12.238). Patients with early latent syphilis were less likely to achieve serological response compared with those with primary or secondary syphilis (AOR, 0.317; 95% CI, 0.142-0.708). However, serological response was not affected by presence of spirochetemia or antibiotic regimens. ? 2013 The Authors Clinical Microbiology and Infection ? 2013 European Society of Clinical Microbiology and Infectious Diseases. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906790619&doi=10.1111%2f1469-0691.12504&partnerID=40&md5=222a98fc8e5a40a6b2f8ca61eef9d4b6 https://scholars.lib.ntu.edu.tw/handle/123456789/588829 |
ISSN: | 1198-743X | DOI: | 10.1111/1469-0691.12504 | SDG/Keyword: | antibiotic agent; antiinfective agent; bacterial DNA; adult; antibiotic therapy; article; blood sampling; CD4 lymphocyte count; disease association; female; human; major clinical study; male; polymerase chain reaction; primary syphilis; priority journal; secondary syphilis; spirochete infection; spirochetemia; syphilis; treatment response; Treponema pallidum; treponematosis; bacteremia; blood; isolation and purification; prevalence; syphilis; Treponema pallidum; Spirochaetales; Treponema pallidum; Adult; Anti-Bacterial Agents; Bacteremia; CD4 Lymphocyte Count; DNA, Bacterial; Female; Humans; Male; Polymerase Chain Reaction; Prevalence; Syphilis; Treponema pallidum |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.