https://scholars.lib.ntu.edu.tw/handle/123456789/589731
標題: | Risk of COPD Exacerbations Associated with Statins versus Fibrates: A New User, Active Comparison, and High-Dimensional Propensity Score Matched Cohort Study | 作者: | Sun, Shu-Hui CHIA-HSUIN CHANG Zhan, Zhe-Wei Chang, Wen-Hsuan Chen, Yu-An Dong, Yaa-Hui |
關鍵字: | active comparison; acute exacerbations; chronic obstructive pulmonary disease; cohort study; high-dimensional propensity score; new users; statins;Active comparison; Acute exacerbations; Chronic obstructive pulmonary disease; Cohort study; High-dimensional propensity score; New users; Statins | 公開日期: | 2021 | 卷: | 16 | 來源出版物: | International journal of chronic obstructive pulmonary disease | 摘要: | Several observational studies have found that statins may materially decrease the risk of chronic obstructive pulmonary disease (COPD) exacerbations. However, most of these studies used a prevalent user, non-user comparison approach, which may lead to overestimation of the clinical benefits of statins. We aimed to explore the risk of COPD exacerbations associated with statins with a new user, active comparison approach to address potential methodological concerns. We selected fibrates, another class of lipid-lowering agents, as the reference group because no evidence suggests that fibrates have an effect on COPD exacerbations. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/589731 | ISSN: | 11769106 | DOI: | 10.2147/COPD.S323391 | SDG/關鍵字: | fibric acid derivative; hydroxymethylglutaryl coenzyme A reductase inhibitor; chronic obstructive lung disease; cohort analysis; disease exacerbation; human; propensity score; Cohort Studies; Disease Progression; Fibric Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Propensity Score; Pulmonary Disease, Chronic Obstructive |
顯示於: | 醫學系 |
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