https://scholars.lib.ntu.edu.tw/handle/123456789/593472
Title: | A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases | Authors: | Wang C.-H. CHUHSING KATE HSIAO CHI-LING CHEN Hsu L.-I. Chiou H.-Y. Chen S.-Y. Hsueh Y.-M. Wu M.-M. Chen C.-J. |
Issue Date: | 2007 | Journal Volume: | 222 | Journal Issue: | 3 | Start page/Pages: | 315-326 | Source: | Toxicology and Applied Pharmacology | Abstract: | Cardiovascular disease is the leading cause of mortality worldwide. Arsenic is a ubiquitous metalloid in the crust of the earth. Chronic arsenic poisoning is becoming an emerging epidemic in Asia. Epidemiological studies have shown that chronic arsenic poisoning through ingestion of arsenic-contaminated water is associated with various cardiovascular diseases in dose-response relationships. These cardiovascular disorders include carotid atherosclerosis detected by ultrasonography, impaired microcirculation, prolonged QT interval and increased QT dispersion in electrocardiography, and clinical outcomes such as hypertension, blackfoot disease (a unique peripheral vascular disease endemic in southwestern Taiwan), coronary artery disease and cerebral infarction. Chronic arsenic poisoning is an independent risk factor for cardiovascular disease. The adverse cardiovascular effects of long-term arsenic exposure may be persistent and/or irreversible. Arsenic-induced cardiovascular diseases in human population may result from the interaction among genetic, environment and nutritional factors. The major adverse cardiovascular effect of chronic arsenic poisoning has been established qualitatively and quantitatively in the high arsenic exposure areas, but the low-dose effect of arsenic on cardiovascular diseases remains to be explored. Cardiovascular death is the major cause of mortality worldwide, and a small increased risk may imply a large quantity of excess mortality. ? 2006 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547586639&doi=10.1016%2fj.taap.2006.12.022&partnerID=40&md5=6b62f5c9edd815099db83f8d532ba6c1 https://scholars.lib.ntu.edu.tw/handle/123456789/593472 |
ISSN: | 0041-008X | DOI: | 10.1016/j.taap.2006.12.022 | SDG/Keyword: | arsenic; arsenic poisoning; article; blackfoot disease; brain atherosclerosis; brain infarction; brain microcirculation; cardiovascular disease; cardiovascular effect; cerebrovascular disease; coronary artery disease; echography; electrocardiogram; environmental exposure; environmental factor; gene interaction; human; hypertension; ischemic heart disease; nutrigenomics; peripheral vascular disease; QT dispersion; QT interval; QT prolongation; Arsenic; Cardiovascular Diseases; Cerebrovascular Disorders; Environmental Exposure; Humans; Myocardial Ischemia; Occupational Exposure; Poisons; Vascular Diseases |
Appears in Collections: | 臨床醫學研究所 |
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