https://scholars.lib.ntu.edu.tw/handle/123456789/597532
Title: | B cells and cancer: To B or not to B? | Authors: | Fridman W.H. Petitprez F. Meylan M. WEI-WU CHEN Sun C.-M. Roumenina L.T. Saut?s-Fridman C. |
Issue Date: | 2021 | Publisher: | Rockefeller University Press | Journal Volume: | 218 | Journal Issue: | 1 | Source: | Journal of Experimental Medicine | Abstract: | Whereas T cells have been considered the major immune cells of the tumor microenvironment able to induce tumor regression and control cancer clinical outcome, a burst of recent publications pointed to the fact that B cells may also play a prominent role. Activated in germinal centers of tertiary lymphoid structures, B cells can directly present tumor-associated antigens to T cells or produce antibodies that increase antigen presentation to T cells or kill tumor cells, resulting in a beneficial clinical impact. Immune complexes can also increase inflammation, angiogenesis, and immunosuppression via macrophage and complement activation, resulting in deleterious impact. ? 2020 Fridman et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101021080&doi=10.1084%2fJEM.20200851&partnerID=40&md5=c15d03b0fffcf1f1f281cdff987654eb https://scholars.lib.ntu.edu.tw/handle/123456789/597532 |
ISSN: | 0022-1007 | DOI: | 10.1084/JEM.20200851 | SDG/Keyword: | tumor antigen; angiogenesis; B lymphocyte; complement activation; germinal center; human; immunosuppressive treatment; inflammation; macrophage; malignant neoplasm; nonhuman; priority journal; Review; T lymphocyte; tertiary lymphoid structure; tumor immunology; animal; B lymphocyte; immunology; neoplasm; neovascularization (pathology); pathology; tumor microenvironment; vascularization; Animals; Antigens, Neoplasm; B-Lymphocytes; Complement Activation; Humans; Inflammation; Macrophages; Neoplasms; Neovascularization, Pathologic; T-Lymphocytes; Tumor Microenvironment |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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