https://scholars.lib.ntu.edu.tw/handle/123456789/600218
標題: | Exosomes - Potential for Blood-Based Marker in Alzheimer’s Disease | 作者: | Li C.-C Hsu W.-F Wo A.M. ANDREW WO |
關鍵字: | Adolescence;Borderline personality disorders;Crime;Data linkage;Violence;Youth;biological marker;messenger RNA;microRNA;nucleic acid;protein;Alzheimer disease;Article;biogenesis;borderline state;cell membrane;cell proliferation;centrifugation;degenerative disease;density gradient centrifugation;endosome;exosome;multivesicular body;nerve cell;nerve degeneration;nonhuman;size exclusion chromatography;ultracentrifugation;violence;human;Alzheimer Disease;Biomarkers;Exosomes;Humans | 公開日期: | 2022 | 卷: | 31 | 期: | 1 | 起(迄)頁: | 1-6 | 來源出版物: | Acta Neurologica Taiwanica | 摘要: | Exosomes are believed to be secreted from multivesicular endosomes and containing proteins and nucleic acids, including mRNA and microRNAs, which have been implicated to play a role in neurodegenerative diseases. Neuron-derived exosomes at the circulation provide a unique potential as biomarkers towards assessment of Alzheimer’s disease (AD), even at the pre-clinical stage. This review briefly discusses their biogenesis and transport, exosomal protein verses soluble protein, evidence for their role in AD, isolation of exosomes, and challenges and future directions to realize reliable blood-based biomarkers to meet phenomenal unmet clinical and pre-clinical need of AD. ? 2022, Neurological Society R.O.C (Taiwan). All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123231278&partnerID=40&md5=0203c5c5b9ec78d76ebe436991f99856 https://scholars.lib.ntu.edu.tw/handle/123456789/600218 |
ISSN: | 1028768X |
顯示於: | 應用力學研究所 |
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