Exosomes - Potential for Blood-Based Marker in Alzheimer’s Disease
Journal
Acta Neurologica Taiwanica
Journal Volume
31
Journal Issue
1
Pages
1-6
Date Issued
2022
Author(s)
Abstract
Exosomes are believed to be secreted from multivesicular endosomes and containing proteins and nucleic acids, including mRNA and microRNAs, which have been implicated to play a role in neurodegenerative diseases. Neuron-derived exosomes at the circulation provide a unique potential as biomarkers towards assessment of Alzheimer’s disease (AD), even at the pre-clinical stage. This review briefly discusses their biogenesis and transport, exosomal protein verses soluble protein, evidence for their role in AD, isolation of exosomes, and challenges and future directions to realize reliable blood-based biomarkers to meet phenomenal unmet clinical and pre-clinical need of AD. ? 2022, Neurological Society R.O.C (Taiwan). All rights reserved.
Subjects
Adolescence
Borderline personality disorders
Crime
Data linkage
Violence
Youth
biological marker
messenger RNA
microRNA
nucleic acid
protein
Alzheimer disease
Article
biogenesis
borderline state
cell membrane
cell proliferation
centrifugation
degenerative disease
density gradient centrifugation
endosome
exosome
multivesicular body
nerve cell
nerve degeneration
nonhuman
size exclusion chromatography
ultracentrifugation
violence
human
Alzheimer Disease
Biomarkers
Exosomes
Humans
SDGs
Type
journal article